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March 16, 2023

Biological impact of sequential exposures to allergens and ultrafine particle-rich combustion aerosol on human bronchial epithelial BEAS-2B cells at the air liquid interface

doi: 10.1002/jat.4458 Elias Josef Zimmermann 1 2, Joana Candeias 3, Nadine Gawlitta 1, Christoph Bisig 1, Stephanie Binder 1 2, […]

February 15, 2023

Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts

https://doi.org/10.1016/j.etap.2023.104079 Jana Pantzke a,b, Arne Koch a, Elias J. Zimmermann a,b, Narges Rastak b, Svenja Offer a,b, Christoph Bisig b, […]

January 18, 2023

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

https://doi.org/10.3390/ijms24031927 Alexandra Friesen 1, Susanne Fritsch-Decker 2, Sonja Mülhopt 3 , Caroline Quarz 1, Jonathan Mahl 3, Werner Baumann 3, […]

November 18, 2022

Rescue of Ciliary Function in Cell-based Primary Ciliary Dyskinesia Models using Nebulized, LNP-formulated mRNA

Rumpa B. Bhattacharjee1, Mirko Hennig1, Daniella Ishimaru1, David Liston1, Jackson K. Eby2, Christian C. Corona1, Ishita Agarwal1 Jade E. Casillas1, […]

November 14, 2022

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

https://doi.org/10.1016/j.impact.2022.100439 Anne Bannuscher a, Otmar Schmid b,c, Barbara Drasler a, Alain Rohrbasser a, Hedwig M. Braakhuis d, Kirsty Meldrum e, Edwin […]

November 3, 2022

Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell® Mammalian 6/48 exposure module

https://doi.org/10.1016/j.toxrep.2022.11.001 Brian M. Keyser1, Robert Leverette1, Michael Hollings2, Adam Seymour2, Randy A. Weidman3, Carlton J. Bequette3, Kristen Jordan1 1 RAI […]

October 13, 2022

Toxicological impact of organic ultrafine particles (UFPs) in human bronchial epithelial BEAS-2B cells at air-liquid interface

https://doi.org/10.1016/j.tiv.2021.105258 A. T. Juarez Facio1, J. Yon2, C. Corbière1, T. Rogez-Florent1, C. Castilla3, H. Lavanant3, M. Mignot3, C. Devouge-Boyer3, C. […]

September 30, 2022

NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene

https://doi.org/10.1016/j.tox.2022.153340 Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen, Scott D. Slattery […]

September 30, 2022

Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

https://doi.org/10.3390/nano12193431 Kirsty Meldrum, Joana A. Moura, Shareen H. Doak and Martin J. D. Clift In Vitro Toxicology Group, Swansea University […]

August 22, 2022

Carbon nanoparticles adversely affect CFTR expression and toxicologically relevant pathways

https://doi.org/10.1038/s41598-022-18098-8 Torben Stermann1, Thach Nguyen1, Burkhard Stahlmecke2, Ana Maria Todea2, Selina Woeste1, Inken Hacheney1, Jean Krutmann1,3, Klaus Unfried1, Roel P. […]

July 29, 2022

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

https://doi.org/10.3390/nano12152609 Laura Maria Azzurra Camassa 1, Elisabeth Elje 2,3, Espen Mariussen 2,4, Eleonora Marta Longhin 2, Maria Dusinska 2, Shan […]

June 21, 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

https://doi.org/10.1016/j.envint.2022.107366 Michal Pardoa, Svenja Offerbc, Elena Hartnerbc, Sebastiano Di Bucchianicob, Christoph Bisigb, Stefanie Bauerb, Jana Pantzkebc, Elias J. Zimmermannbc, XinCaobc, […]

June 15, 2022

Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48

DOI: 10.1089/aivt.2022.0001 Brian M. Keyser,1 Robert Leverette,1 Michael Hollings,2 Adam Seymour,2 Randy J. Weidman,3 Carlton J. Bequette,3 and Kristen Jordan1 […]

April 15, 2022

Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction

https://doi.org/10.3390/nano12081362 Mélanie M. Leroux 1 , Romain Hocquel 1, Kevin Bourge 1 , Boštjan Kokot 2 , Hana Kokot 2 , […]

April 15, 2022

Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction

https://doi.org/10.3390/nano12081362 Mélanie M. Leroux 1 , Romain Hocquel 1, Kevin Bourge 1 , Boštjan Kokot 2 , Hana Kokot 2 […]

March 27, 2022

Nrf2 Responses of Commercial Cigarette Whole Smoke and Aerosol from Six Electronic Nicotine Delivery Systems (ENDS) in a 3D Human Airway Model

Brian M. Keyser1, John Wertman1, Michael Hollings2, Robert Bedford2, and Kristen Jordan1 1 Scientific & Regulatory Affairs, RAI Services Company, […]

March 27, 2022

Cytotoxicity Assessment of Electronic Nicotine Delivery Systems (ENDS) and Combustible Cigarette Aerosols Utilizing Standard and Whole Aerosol Exposure Approaches in the Neutral Red Uptake Assay

Robert Leverette1, Thomas Shutsky1, John Wertman1, Katarina Aleksa2, Dhatri Lakshmanan2, Rebecca Payne3, Kristen Jordan1 1Scientific & Regulatory Affairs, RAI Services […]

March 27, 2022

In Vitro Cytotoxicity Assessment of 3D Human Airway Tissue Following Exposure to Whole Aerosol/Smoke Generated from Electronic and Combustible Cigarettes

Thomas Shutsky1, Brian M. Keyser1, Kristen Jordan1, Michael Hollings2, and Emma Rothwell2 1Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, […]

March 22, 2022

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium

https://doi.org/10.1172/jci.insight.155589 Kristine M. Abo,1,2 Julio Sainz de Aja,3,4,5 Jonathan Lindstrom-Vautrin,1 Konstantinos-Dionysios Alysandratos,1,2 Alexsia Richards,6 Carolina Garcia-de-Alba,3,4,5 Jessie Huang,1,2 Olivia T. […]

March 18, 2022

Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol

https://doi.org/10.1016/j.tiv.2022.105352 J. Zhang1, U. Doshi1, R.L. Wolz2, P. Kosachevsky2, M.J. Oldham1,2, I.G. Gillman2,2 , K.M. Lee1 1Altria Client Services LLC, […]

March 1, 2022

The priming effect of diesel exhaust on native pollen exposure at the air-liquid interface

https://doi.org/10.1016/j.envres.2022.112968 Joana Candeiasa, Elias J. Zimmermannbc, Christoph Bisigb, Nadine Gawlittabc, Sebastian Oederb, Thomas Grögerb, Ralf Zimmermannbc, Carsten B. Schmidt-Webera, Jeroen […]

February 7, 2022

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

Aditya R. Kolli, 1 Tanja Zivkovic Semren, 1 David Bovard, 1 Shoaib Majeed, 1 Marco van der Toorn, 1 Sophie […]

February 3, 2022

Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs

https://doi.org/10.1289/EHP9413 Svenja Offer,1,2Elena Hartner,1,2Sebastiano Di Bucchianico,1Christoph Bisig,1Stefanie Bauer,1Jana Pantzke,1,2Elias J. Zimmermann,1,2Xin Cao,1,2Stefanie Binder,1,2Evelyn Kuhn,1Anja Huber,1Seongho Jeong,1,2Uwe Käfer,1,2Patrick Martens,2Arunas Mesceriakovas,3Jan Bendl,1,4,5Ramona […]

February 1, 2022

Automation and Standardization—A Coupled Approach Towards Reproducible Sample Preparation Protocols for Nanomaterial Analysis

https://doi.org/10.3390/molecules27030985 Jörg Radnik 1, Vasile-Dan Hodoroaba 1, Harald Jungnickel 2, Jutta Tentschert 2, Andreas Luch 2, Vanessa Sogne 3, Florian […]

December 9, 2021

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia

https://doi.org/10.1016/j.bbrep.2021.101187 David Bovard b, Marco van der Toorn b, Walter K. Schlage a, Samuel Constant c, Kasper Renggli b, Manuel […]

November 27, 2021

Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface

https://doi.org/10.3390/nano11123226 Sivakumar Murugadoss 1, Sonja Mülhopt 2, Silvia Diabaté 3, Manosij Ghosh 1, Hanns-Rudolf Paur 2, Dieter Stapf 2, Carsten […]

October 11, 2021

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air–liquid interface in exposure concentrations relevant at workplaces

https://doi.org/10.1002/em.22464 Stephanie Binder1,2, Xin Cao1,2, Stefanie Bauer1, Narges Rastak1, Evelyn Kuhn1, George C. Dragan3, Christian Monseé4, George Ferron1, Dietmar Breuer5, […]

June 27, 2021

Impact of Nanocomposite Combustion Aerosols on A549 Cells and a 3D Airway Model

https://doi.org/10.3390/nano11071685 Matthias Hufnagel 1, Nadine May 2, Johanna Wall 1, Nadja Wingert 3, Manuel Garcia-Käufer 3, Ali Arif 3, Christof […]

June 21, 2021

In vitro hazard characterization of simulated aircraft cabin bleed-air contamination in lung models using an air-liquid interface (ALI) exposure system

https://doi.org/10.1016/j.envint.2021.106718 Rui-Wen He a,b, Marc M.G. Houtzager c, W.P. Jongeneel a, Remco H.S. Westerink b, Flemming R. Cassee a,b a […]

June 15, 2021

VITROCELL® Cloud Alpha - A Family of Exposure Systems Suitable for Nebulized Solutions and Suspensions

Patrick Weindl, Heidi Ortolf-Wahl, Tobias Krebs VITROCELL Systems GmbH, 79183 Waldkirch, Germany Optimal Solution for Everyday Experiments at the […]

June 2, 2021

Development of a standardized in vitro approach to evaluate microphysical, chemical, and toxicological properties of combustion-derived fine and ultrafine particles

https://doi.org/10.1016/j.jes.2021.06.001 Ana Teresa Juarez-Facio 1, Clément Castilla 2, Cécile Corbière 1, Hélène Lavanant 2, Carlos Afonso 2, Christophe Morin 2, […]

April 20, 2021

An In Vitro Air-Liquid Interface Inhalation Platform for Petroleum Substances and Constituents

DOI: 10.14573/altex.2010211 Sandra Verstraelen1, An Jacobs1, Jo Van Laer1, Karen Hollanders1, Masha Van Deun2, Diane Bertels2, Rob Brabers1, Hilda Witters1, […]

February 15, 2021

Impact of Sea Breeze Dynamics on Atmospheric Pollutants and Their Toxicity in Industrial and Urban Coastal Environments

doi:10.3390/rs12040648 Patrick Augustin 1, Sylvain Billet 2 , Suzanne Crumeyrolle 3, Karine Deboudt 1, Elsa Dieudonné 1 , Pascal Flament […]

January 29, 2021

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

DOI: 10.3389/fbioe.2021.616830 Ali Doryab 1,2, Mehmet Berat Taskin 3, Philipp Stahlhut 3, Andreas Schröppel 1,2, Sezer Orak 1,2, Carola Voss […]

January 14, 2021

Toxic effects of gunshot fumes from different ammunitions for small arms on lung cells exposed at the air liquid interface

https://doi.org/10.1016/j.tiv.2021.105095 Espen Mariussen a,b, Lise Fjellsbø a,c, Tomas Roll Frømyr b, Ida Vaa Johnsen b, Tove Engen Karsrud b, Øyvind […]

December 29, 2020

Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects

https://doi.org/10.3390/nano11010065 Silvia Diabaté 1, Lucie Armand 2, Sivakumar Murugadoss 1 , Marco Dilger 1 , Susanne Fritsch-Decker 1, Christoph […]

December 2, 2020

Toxicological responses of BEAS-2B cells to repeated exposures to benzene, toluene, m-xylene, and mesitylene using air–liquid interface method

DOI: 10.1002/jat.4113 Clémence Méausoone1, Yann Landkocz1, Fabrice Cazier2, Marianne Seigneur1, Dominique Courcot1, Sylvain Billet1 1 Unité de Chimie Environnementale et […]

November 28, 2020

Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles

doi:10.3390/nano10122369 Lars B. Leibrock 1, Harald Jungnickel 1, Jutta Tentschert 1, Aaron Katz 1, Blaza Toman 2 , Elijah J. […]

November 19, 2020

Sub‑ohm vaping increases the levels of carbonyls, is cytotoxic, and alters gene expression in human bronchial epithelial cells exposed at the air–liquid interface

https://doi.org/10.1186/s12931-020-01571-1 Alexandra Noël, Ekhtear Hossain, Zakia Perveen, Hasan Zaman and Arthur L. Penn Department of Comparative Biomedical Sciences, School of […]

November 18, 2020

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

https://doi.org/10.1016/j.toxlet.2020.11.006 Albert Giralta, Anita R Iskandara, FlorianMartina, ElisaMoschinib, TomassoSerchib, AthanasiosKondylisa, DiegoMarescottia, PatriceLeroya, LauraOrtega-Torresa, ShoaibMajeeda, CelineMerga, KeyurTrivedia, EmmanuelGuedja,StefanFrentzela, Nikolai V Ivanova, Manuel […]

November 15, 2020

The Comparative Analysis of Cytokine Production by a Human 3D Tissue Model Following Exposure to Traditional Cigarette Smoke, Tobacco-Heated Product and E-Cigarette Aerosol

Rob Bedford1, Emma Rothwell1, Sophie Martin1, Cian O’Hanlon1, Andrew McCune2 and Michael Hollings1 1Genetic and Molecular Toxicology and 2Immunology and […]

November 11, 2020

Exposure of cellulose nanocrystals on human lung cells at the air-liquid-interface

Michelle Hesler1, Annika Kittel1, Stephan Dähnhardt-Pfeiffer2, Christoph Metzger3, Christine Herrmann3, Marielle Fink4, Heiko Briesen3, Tobias Krebs4, Hagen von Briesen1, Sylvia […]

November 2, 2020

Toxicological responses of BEAS-2B cells to repeated exposures to benzene, toluene, m-xylene, and mesitylene using air–liquid interface method

DOI: 10.1002/jat.4113 Clémence Méausoone1, Yann Landkocz1, Fabrice Cazier2, Marianne Seigneur1 Dominique Courcot1, Sylvain Billet1 1Unité de Chimie Environnementale et Interactions […]

November 2, 2020

Influence of the environmental relative humidity on the inflammatory response of skin model after exposure to various environmental pollutants

https://doi.org/10.1016/j.envres.2020.110350 Emeline Seurat a, Anthony Verdin b, Fabrice Cazier c, Dominique Courcot b, Richard Fitoussi d, Katell Vi´e d, Val´erie […]

October 31, 2020

Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures

https://doi.org/10.1016/j.jaerosci.2020.105703 Rui-Wen He a,b, Hedwig M. Braakhuis a, Rob J. Vandebriel a, Yvonne C.M. Staal a, Eric R. Gremmer […]

October 17, 2020

Cell‑specific toxicity of short‑term JUUL aerosol exposure to human bronchial epithelial cells and murine macrophages exposed at the air–liquid interface

https ://doi.org/10.1186/s1293 1-020-01539-1 Rakeysha Pinkston1,2, Hasan Zaman2, Ekhtear Hossain2, Arthur L. Penn2 and Alexandra Noël2 1 Department of Environmental Toxicology, […]

October 8, 2020

Alternative air–liquid interface method for inhalation toxicity testing of a petroleum-derived substance

https://doi.org/10.1016/j.mex.2020.101088 Verstraelen Sandra a , Jacobs An a , Van Laer Jo a , Van Deun Masha b , Bertels […]

September 29, 2020

Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives

https://doi.org/10.1007/s11626-020-00517-7 Xuefei Cao1, Jayme P. Coyle2, Rui Xiong1, Yiying Wang1, Robert H. Heflich1, Baiping Ren1, William M. Gwinn3, Patrick Hayden4, […]

September 28, 2020

NanoCELL - Comprehensive characterization and human toxicological assessment of cellulose nanocrystals along their life cycle for reliable risk assessment

Yvonne Kohl1, Roland Drexel2, Christine Herrmann3, Stephan Dähnhardt-Pfeiffer4, Siegfried Fürtauer5, Michelle Hesler1, Christoph Metzger3, Marielle Fink6, Dominik Selzer7, Thorsten Lehr7, […]

September 16, 2020

Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems

https://doi.org/10.1186/s12989-020-00376-w Yaobo Ding1,2 , Patrick Weindl1,2,3, Anke-Gabriele Lenz1,2, Paula Mayer1,2, Tobias Krebs3 and Otmar Schmid1,2 1Institute of Lung Biology and […]

August 27, 2020

Comparative anti-inflammatory effect of curcumin at air-liquid interface and submerged conditions using lipopolysaccharide stimulated human lung epithelial A549 cells

https://doi.org/10.1016/j.pupt.2020.101939 Yue Hu a,b,c, Yunhua Sheng c,e, Xiaoli Ji c,e, Ping Liu c,e, Liming Tang c,e, Gang Chen a,Guiliang Chen […]

August 15, 2020

Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure

https://doi.org/10.1016/j.tiv.2020.104968 Artik Mistry, Larry E. Bowen, Michael W. Dzierlenga, Jessica K. Hartman, Scott D. Slattery ScitoVation, LLC, Durham, NC 27713, […]

July 27, 2020

An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols

doi:10.3390/ijms21155335 Hana Barosova 1,2 , Bedia Begum Karakocak 1 , Dedy Septiadi 1 , Alke Petri-Fink 1,3, Vicki Stone 4 […]

July 26, 2020

Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air–liquid interface

https://doi.org/10.1016/j.tiv.2020.104950 Authors Rui-WenHeab, Miriam E.Gerlofs-Nijlanda, JohnBoerea, PaulFokkensa, DaanLesemana, Nicole A.H.Janssena, Flemming R.Casseeab a National Institute for Public Health and the […]

July 13, 2020

An experimental aerosol air–agar interface mouse lymphoma assay methodology

DOI: https://doi.org/10.1016/j.mrgentox.2020.503230 Authors Thorne D1, Hollings M2, Kilford J2, Clements J2, Payne R2, Ballantyne M2, Dalrymple, A1, Dillon, D1, Meredith, […]

May 21, 2020

A novel TEM grid sampler for airborne particles to measure the cell culture surface dose

Sonja Mülhopt1, Christoph Schlager2, Markus Berger2, Sivakumar Murugadoss3, Peter H. Hoet3, Tobias Krebs2, Hanns-Rudolf paur1 & Dieter Stapf1 1Karlsruhe Institute […]

May 13, 2020

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

DOI:10.3791/61210 Hedwig M. Braakhuis1, Ruiwen He1,2, Rob J. Vandebriel1, Eric R. Gremmer1, Edwin Zwart1, Jolanda P. Vermeulen1, Paul Fokkens1, John […]

April 14, 2020

Toxicity and Gene Expression Profiling of Copper- and Titanium-Based Nanoparticles Using Air–Liquid Interface Exposure

https://doi.org/10.1021/acs.chemrestox.9b00489 Matthias Hufnagel, Sarah Schoch, Johanna WallBettina, Maria Strauch, Andrea Hartwig Department of Food Chemistry and Toxicology, Institute of Applied […]

March 26, 2020

New lung model gives lab animals a breather

Autor Francesca Lake Source Barosova H, Maione AG, Septiadi D et al. Use of EpiAlveolar lung model to predict fibrotic […]

March 24, 2020

Comparison of Vapor and Liquid Phase Acrolein Exposures to Air Liquid Interface (ALI) Cell Cultures

David H. Brandwein, F. Adam Bettmann, Michael P. DeLorme, Alan T. Eveland, Lawrence M. Milchak 3M Corporate Toxicology and Environmental […]

March 20, 2020

Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes

https://dx.doi.org/10.1021/acsnano.9b06860 Autors Barosova H1, Maione AG2, Septiadi D1, Sharma M3, Haeni L1, Balog S1, O'Connell O2, Jackson GR2, Brown D4, […]

February 28, 2020

Lung Cell Exposure to Secondary Photochemical Aerosols Generated From OH Oxidation of Cyclic Siloxanes

DOI: 10.1016/j.chemosphere.2019.125126 Autors Benjamin M King 1 , Nathan J Janechek 1 , Nathan Bryngelson 1 , Andrea Adamcakova-Dodd 2 […]

February 25, 2020

Comparison of in vitro toxicity of aerosolized engineered nanomaterials using air-liquid interface mono-culture and co-culture models

https://doi.org/10.1016/j.impact.2020.100215 Autors Yifang Wanga, Andrea,Adamcakova-Doddb, Benjamin R.Steinesb, Xuefang Jingb, Aliasger K.Salemc, Peter S.Thorneab a Human Toxicology Interdisciplinary Program, University of […]

February 24, 2020

In vitro advances in whole aerosol approaches for e-cigarette testing

Autor David Thorne, British American Tobacco Workshop series to identify, discuss and develop recommendations for the optimal generation and […]

February 19, 2020

Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cellcultures

doi: 10.1016/j.tiv.2020.104798 Autors Medina-Reyes EI1, Delgado-Buenrostro NL2, Leseman DL3, Déciga-Alcaraz A2, He R4, Gremmer ER3, Fokkens PHB3, Flores-Flores JO5, Cassee […]

January 15, 2020

Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward.

https://doi.org/10.1016/j.mrgentox.2020.503135 Authors StefanPfuhlera, Janvan Benthemb, RodgerCurrenc, Shareen H.Doakd, MariaDusinskae, MakotoHayashif, Robert H.Heflichg, DarrenKiddh, DavidKirklandi, YangLuanj, GladysOuedraogok, KerstinReisingerl, ToshioSofunim, Frédériquevan Ackern, […]

December 31, 2019

High Throughput Air Liquid Interface Exposure Modules: Characterization of Smoke/Aerosol Dosimetry and in vitro Mutagenicity and Cytotoxicity of Two Tobacco Product Types

Robert Leverette1, Brian Keyser1, Michael Hollings2 and Adam Seymour2 1RAI Services Company, Winston−Salem, NC 27101 USA 2Covance Laboratories Ltd., Harrogate, […]

November 30, 2019

Characterization of Whole Mainstream Smoke/Aerosol Delivery within the Vitrocell® Ames 48 High Throughput Exposure Module Using Different Tobacco Product Types.

1Leverette R, 1Keyser B, 2Seymour A and 2Hollings M 1Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, NC 27101 2Covance […]

November 30, 2019

Dosimetric Analysis of Aerosol Generated by a Vitrocell® VC10® Smoking Robot – Investigations on Dose Dependency and Consistency of Application

Adam Seymour, Michael Hollings, Joanne Larner and Julie Clements; Covance Laboratories Ltd, Harrogate, UK QCMs were used to assess the […]

November 27, 2019

State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-notburn tobacco products

Stéphanie Boué1, Didier Goedertier1, Julia Hoeng1 , Arkadiusz Kuczaj1, Shoaib Majeed1, Carole Mathis1, Anne May2 , Blaine Phillips3, Manuel C […]

November 4, 2019

Investigation of multiple whole smoke dosimetry techniques using a VITROCELL®VC10® smoke exposure system

https://doi.org/10.1016/j.toxrep.2019.10.011 Brian M. Keysera, Robert Leverettea, Michael Hollingsb, Adam Seymourb, Lesley Reeveb, Wanda Fieldsa a RAI Services Company, Scientific & […]

November 1, 2019

Electronic Cigarette Vapor With Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors

DOI: 10.1164/rccm.201811-2087OC Samuel Chung 1 2, Nathalie Baumlin 1 2, John S Dennis 1 2, Robert Moore 2, Sebastian F […]

October 31, 2019

Deposition efficiency and uniformity of monodisperse solid particle deposition in the Vitrocell® 24/48 Air–Liquid-Interface in vitro exposure system

DOI: 10.1080/02786826.2019.1676877 Michael J. Oldhama , Nicolas Castroa, Jingjie Zhanga, Ali Rostamia, Francesco Luccib, Yezdi Pithawallaa, Arkadiusz K. Kuczajb,c , […]

October 25, 2019

VITROCELL® High Throughput Exposure Module: Deposition and Cytotoxicity of Smoke/Aerosol from Different Tobacco Product Types

1Leverette R, 1Keyser B, 2Seymour A, 2Hollings M and 1Bombick B 1Scientific & Regulatory Affairs, RAI Services Company Winston-Salem, NC […]

October 25, 2019

Vitrocell® High Throughput Exposure Module: Deposition and Cytotoxicity of Smoke/Aerosol from Different Tobacco Product Types

October 25, 2019

New holder for ENDS products for VITROCELL® Smoking Machines and Robots

Bastian Gutmann, Tobias Krebs VITROCELL Systems GmbH 79183 Waldkirch, Germany The poster shows the new holder for ENDS products Background […]

October 25, 2019

VITROCELL® Quality Management System Certification

Patricia Hebestreit, Tobias Krebs VITROCELL Systems GmbH 79183 Waldkirch, Germany The poster shows our quality policy, we increase under ISO 9001:2015. […]

October 15, 2019

Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes

DOI: 10.1016/j.chemosphere.2019.125126 Autors King BM1, Janechek NJ1, Bryngelson N1, Adamcakova-Dodd A2, Lersch T3, Bunker K3, Casuccio G3, Thorne PS2, Stanier […]

September 7, 2019

Application of a multi‑layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e‑liquid and its corresponding aerosol using an e‑cigarette device

https://doi.org/10.1007/s00204-019-02565-9 Anita R. Iskandar, Filippo Zanetti, Diego Marescotti, Bjorn Titz, Alain Sewer, Athanasios Kondylis, Patrice Leroy, Vincenzo Belcastro, Laura Ortega […]

August 22, 2019

PETA International Science Group and Tobacco Companies Donate to Save Animals

Gaithersburg, Md. – The PETA International Science Consortium Ltd., Imperial Brands PLC, Altria Client Services (ALCS), British American Tobacco (BAT) […]

August 11, 2019

Exposure to aerosols from electronic cigarettes using the MESH™ technology has a reduced biological impact on bronchial epithelial cell cultures compared with exposure to cigarette smoke

Albert Giralt, Florian Martin, Anita R. Iskandar, Alain Sewer, Laura Ortega Torres, AthanasiosKondylis, Patrice Leroy, Celine Merg, ShoaibMajeed, Emmanuel Guedj, […]

June 26, 2019

PETA Science Group Donates $50,000 in Equipment to Pioneering Laboratory

The PETA International Science Consortium Ltd. is donating $50,000 in equipment to the Institute for In Vitro Sciences (IIVS), a […]

June 12, 2019

Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model

DOI: 10.1021/acsnano.9b01823 Ingeborg Kooter1, Marit Ilves 2, Mariska Gröllers-Mulderij 1, Evert Duistermaat 3, Peter C. Tromp 1, Frieke Kuper 1, […]

May 27, 2019

Characterization of the Vitrocell® Cloud SEQ 24 System and its Application in Exposure to Aerosolized Bortezomib and Ibuprofen

S. Steiner1, Sandra Ferreira1, Moran Morelli1, Audrey Baldi1, Arkadiusz K. Kuczaj1, Stefan Frentzel1, Marco van der Toorn1, Manuel Peitsch1, Julia […]

May 25, 2019

In vitro model for the prediction of respiratory sensitization of inhaled chemicals and protein allergens

Weber P. 1, Chary A.1,2, Saibene M. 1, Serchi T.1, Cambier S.1 , Moschini E.1, Contal S.1, Hennen J.2, Ezendam […]

April 5, 2019

Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model

https://doi.org/10.1016/j.tiv.2019.04.007 Yiying Wanga, Qiangen Wub, Levan Muskhelishvilic, Kelly Davisc, Matthew Bryantb, Xuefei Caoa a Division of Genetic and Molecular Toxicology, […]

April 2, 2019

In vitro exposure of a 3D-tetraculture representative for the alveolar barrier at the air-liquid interface to silver particles and nanowires

https://doi.org/10.1186/s12989-019-0297-1 Ionel Fizeșan1, Sébastien Cambier2, Elisa Moschini2, Aline Chary2, Inge Nelissen3, Johanna Ziebel2, Jean-Nicolas Audinot4, Tom Wirtz4, Marcin Kruszewski5,6, Anca […]

March 22, 2019

In vitro toxicological evaluation of emissions from catalytic oxidation removal of industrial VOCs by air/liquid interface (ALI) exposure system in repeated mode.

DOI: 10.1016/j.tiv.2019.03.030 Méausoone C1, El Khawaja R1, Tremolet G1, Siffert S1, Cousin R1, Cazier F2, Billet S1, Courcot D3, Landkocz […]

March 6, 2019

Carbendazim induces death in alveolar epithelial cells: A comparison between submerged and at the air-liquid interface cell culture.

DOI: 10.1016/j.tiv.2019.03.004 Tollstadius BF, da Silva ACG, Oliveira BC, Pedralli, Valadares MC. Laboratory of Education and Research in In vitro […]

March 5, 2019

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

DOI:10.1007/s11739-019-02055-x Filippo Zanetti1, Athanasios Kondylis1, Florian Martin1, Patrice Leroy1, Shoaib Majeed1, Sandro Steiner1, Yang Xiang1, Laura Ortega Torres1, Keyur Trivedi1, […]

February 20, 2019

An in vitro coculture system for the detection of sensitization following aerosol exposure

DOI:10.14573/altex.1901241 Aline Chary1,2, Tommaso Serchi1, Elisa Moschini1, Jennifer Hennen2, Sébastien Cambier1, Janine Ezendam3, Brunhilde Blömeke2 and Arno C. Gutleb1 1Department […]

February 2, 2019

Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model.

DOI: 10.1016/j.yrtph.2019.01.036 Czekala L1, Simms L2, Stevenson M2, Tschierske N2, Maione AG3, Walele T2. 1 Imperial Brands PLC, 121 Winterstoke […]

December 20, 2018

Establishing the Vitrocell® Powder Chamber as a particle size-selective platform for in vitro dry powder testing

S. Steiner1 , M. Hittinger2 , K. Knoth2 , H. Gross2 , S. Frentzel1 , A. Kuczaj1 , J. Hoeng1 […]

December 18, 2018

Development of a quantitative method for assessment of dose in in vitro evaluations using a VITROCELL® VC10® smoke exposure system

https://doi.org/10.1016/j.tiv.2018.12.010 Brian M. Keysera, Robert Leverettea, Kathy Fowlera, Wanda Fieldsa, Victoria Hargreavesb, Lesley Reeveb, Betsy Bombicka a RAI Services Company1, […]

October 28, 2018

Big tobacco embraces in vitro toxicology

c&en, Volume 96, Issue 43 Britt E. Erickson The complexity of next-generation tobacco products has increased by a number of […]

July 26, 2018

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier

DOI: 10.1089/jamp.2017.1364 Ivana d’Angelo, PhD,1 Gabriella Costabile, PhD,2,3 Estelle Durantie, PhD,3 Paola Brocca, PhD,4 Valeria Rondelli, PhD,4 Annapina Russo, PhD,5 […]

July 9, 2018

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures.

DOI: 10.1016/j.tiv.2018.06.024 Steiner S, Diana P, Dossin E, Guy P, Vuillaume G, Kondylis A, Majeed S, Frentzel S, Hoeng J […]

June 30, 2018

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

DOI 10.1016/j.jaerosci.2018.06.015 Francesco Luccia, Nicolas D. Castrob, Ali A. Rostamib, Michael J. Oldhamb, Julia Hoenga, Yezdi B. Pithawallab, Arkadiusz […]

June 6, 2018

Distribution of polymer-coated gold nanoparticles in a 3D lung model and indication of apoptosis after repeated exposure

DOI: 10.2217/nnm-2017-0358 Savvina Chortarea1,2, Kleanthis Fytianos1,3,4, Laura Rodriguez-Lorenzo1, Alke Petri-Fink1,5 & Barbara Rothen-Rutishauser1 1BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, […]

June 1, 2018

Charakterisierung von Partikelemissionen aus dem Trennschleifprozess von kohlefaserverstärktem Beton (Carbonbeton)

Autoren: Hillemann, L.; Stintz, M.; Streibel, T.; Zimmermann, R.; Öder, S.; Kasurinen, S.; di Bucchianico, S.; Kanashova, T.; Dittmar, G.; […]

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