News

March 16, 2023

Biological impact of sequential exposures to allergens and ultrafine particle-rich combustion aerosol on human bronchial epithelial BEAS-2B cells at the air liquid interface

doi: 10.1002/jat.4458 Elias Josef Zimmermann 1 2, Joana Candeias 3, Nadine Gawlitta 1, Christoph Bisig 1, Stephanie Binder 1 2, […]

March 9, 2023

Society of Toxicology's 62nd Annual Meeting and ToxExpo

Taking place in Nashville, Tennessee, the SOT 62nd Annual Meeting and ToxExpo will feature more than 70 Featured and Scientific […]

February 15, 2023

Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts

https://doi.org/10.1016/j.etap.2023.104079 Jana Pantzke a,b, Arne Koch a, Elias J. Zimmermann a,b, Narges Rastak b, Svenja Offer a,b, Christoph Bisig b, […]

January 19, 2023

2023 User Group Meeting

We wish to invite you to participate at our User Group Meeting 2023, an excellent opportunity to discuss our latest […]

January 18, 2023

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

https://doi.org/10.3390/ijms24031927 Alexandra Friesen 1, Susanne Fritsch-Decker 2, Sonja Mülhopt 3 , Caroline Quarz 1, Jonathan Mahl 3, Werner Baumann 3, […]

November 18, 2022

Rescue of Ciliary Function in Cell-based Primary Ciliary Dyskinesia Models using Nebulized, LNP-formulated mRNA

Rumpa B. Bhattacharjee1, Mirko Hennig1, Daniella Ishimaru1, David Liston1, Jackson K. Eby2, Christian C. Corona1, Ishita Agarwal1 Jade E. Casillas1, […]

November 14, 2022

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

https://doi.org/10.1016/j.impact.2022.100439 Anne Bannuscher a, Otmar Schmid b,c, Barbara Drasler a, Alain Rohrbasser a, Hedwig M. Braakhuis d, Kirsty Meldrum e, Edwin […]

November 3, 2022

Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell® Mammalian 6/48 exposure module

https://doi.org/10.1016/j.toxrep.2022.11.001 Brian M. Keyser1, Robert Leverette1, Michael Hollings2, Adam Seymour2, Randy A. Weidman3, Carlton J. Bequette3, Kristen Jordan1 1 RAI […]

October 28, 2022

ESTIV 2022 - International Congress of the European Society of Toxicology In Vitro

VITROCELL will participate in the 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022), held […]

October 27, 2022

VITROCELL® sQCM 12: Data Interpretation

The Quartz Crystal Microbalance is a powerful tool for dosimetry in VITROCELL Exposure Systems. However, interpreting live-data from a sQCM […]

October 13, 2022

Toxicological impact of organic ultrafine particles (UFPs) in human bronchial epithelial BEAS-2B cells at air-liquid interface

https://doi.org/10.1016/j.tiv.2021.105258 A. T. Juarez Facio1, J. Yon2, C. Corbière1, T. Rogez-Florent1, C. Castilla3, H. Lavanant3, M. Mignot3, C. Devouge-Boyer3, C. […]

September 30, 2022

NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene

https://doi.org/10.1016/j.tox.2022.153340 Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen, Scott D. Slattery […]

September 30, 2022

Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

https://doi.org/10.3390/nano12193431 Kirsty Meldrum, Joana A. Moura, Shareen H. Doak and Martin J. D. Clift In Vitro Toxicology Group, Swansea University […]

September 26, 2022

Product News 06-9/2022

For fully automated and repeated row-by-row exposure of 12-, 24- and 96-well sized cell culture inserts. Testing of up to […]

September 9, 2022

ICT 2022 - International Congress of Toxicology

After an intensive preparation period, it is with great pleasure that the Dutch Society of Toxicology (NVT) is welcoming […]

August 22, 2022

Carbon nanoparticles adversely affect CFTR expression and toxicologically relevant pathways

https://doi.org/10.1038/s41598-022-18098-8 Torben Stermann1, Thach Nguyen1, Burkhard Stahlmecke2, Ana Maria Todea2, Selina Woeste1, Inken Hacheney1, Jean Krutmann1,3, Klaus Unfried1, Roel P. […]

July 29, 2022

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

https://doi.org/10.3390/nano12152609 Laura Maria Azzurra Camassa 1, Elisabeth Elje 2,3, Espen Mariussen 2,4, Eleonora Marta Longhin 2, Maria Dusinska 2, Shan […]

June 21, 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

https://doi.org/10.1016/j.envint.2022.107366 Michal Pardoa, Svenja Offerbc, Elena Hartnerbc, Sebastiano Di Bucchianicob, Christoph Bisigb, Stefanie Bauerb, Jana Pantzkebc, Elias J. Zimmermannbc, XinCaobc, […]

June 15, 2022

Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48

DOI: 10.1089/aivt.2022.0001 Brian M. Keyser,1 Robert Leverette,1 Michael Hollings,2 Adam Seymour,2 Randy J. Weidman,3 Carlton J. Bequette,3 and Kristen Jordan1 […]

June 1, 2022

Product News 05-4/2022

For cell culture exposure to smallest quantities of dry powders The VITROCELL® PowderX allows for aerosolisation of small quantities of […]

April 15, 2022

Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction

https://doi.org/10.3390/nano12081362 Mélanie M. Leroux 1 , Romain Hocquel 1, Kevin Bourge 1 , Boštjan Kokot 2 , Hana Kokot 2 , […]

April 15, 2022

Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction

https://doi.org/10.3390/nano12081362 Mélanie M. Leroux 1 , Romain Hocquel 1, Kevin Bourge 1 , Boštjan Kokot 2 , Hana Kokot 2 […]

April 11, 2022

Product News 04-3/2022

Aerosol exposure for breathing AX Lung-on-Chip The VITROCELL® Cloud Alpha AX12 is our newest innovation in the Cloud family and […]

April 6, 2022

Product News 04-2/2022

Manual smoking machine with high tech features The VC 1 smoking machine is used for a controlled aerosol generation of […]

April 4, 2022

Product News 04-1/2022

Increase of nebulizations and evacuation of residual gaseous compounds A typical Cloud exposure allows 3 consecutive nebulizations. The PowerVent option […]

March 27, 2022

Nrf2 Responses of Commercial Cigarette Whole Smoke and Aerosol from Six Electronic Nicotine Delivery Systems (ENDS) in a 3D Human Airway Model

Brian M. Keyser1, John Wertman1, Michael Hollings2, Robert Bedford2, and Kristen Jordan1 1 Scientific & Regulatory Affairs, RAI Services Company, […]

March 27, 2022

Cytotoxicity Assessment of Electronic Nicotine Delivery Systems (ENDS) and Combustible Cigarette Aerosols Utilizing Standard and Whole Aerosol Exposure Approaches in the Neutral Red Uptake Assay

Robert Leverette1, Thomas Shutsky1, John Wertman1, Katarina Aleksa2, Dhatri Lakshmanan2, Rebecca Payne3, Kristen Jordan1 1Scientific & Regulatory Affairs, RAI Services […]

March 27, 2022

In Vitro Cytotoxicity Assessment of 3D Human Airway Tissue Following Exposure to Whole Aerosol/Smoke Generated from Electronic and Combustible Cigarettes

Thomas Shutsky1, Brian M. Keyser1, Kristen Jordan1, Michael Hollings2, and Emma Rothwell2 1Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, […]

March 22, 2022

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium

https://doi.org/10.1172/jci.insight.155589 Kristine M. Abo,1,2 Julio Sainz de Aja,3,4,5 Jonathan Lindstrom-Vautrin,1 Konstantinos-Dionysios Alysandratos,1,2 Alexsia Richards,6 Carolina Garcia-de-Alba,3,4,5 Jessie Huang,1,2 Olivia T. […]

March 18, 2022

Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol

https://doi.org/10.1016/j.tiv.2022.105352 J. Zhang1, U. Doshi1, R.L. Wolz2, P. Kosachevsky2, M.J. Oldham1,2, I.G. Gillman2,2 , K.M. Lee1 1Altria Client Services LLC, […]

March 1, 2022

The priming effect of diesel exhaust on native pollen exposure at the air-liquid interface

https://doi.org/10.1016/j.envres.2022.112968 Joana Candeiasa, Elias J. Zimmermannbc, Christoph Bisigb, Nadine Gawlittabc, Sebastian Oederb, Thomas Grögerb, Ralf Zimmermannbc, Carsten B. Schmidt-Webera, Jeroen […]

February 7, 2022

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

Aditya R. Kolli, 1 Tanja Zivkovic Semren, 1 David Bovard, 1 Shoaib Majeed, 1 Marco van der Toorn, 1 Sophie […]

February 3, 2022

Product News 02-1/2022

For liquid droplet sizes 9 – 12 μm with diffusor Certain chemicals or formulations, for example nasal sprays, often have […]

February 3, 2022

Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs

https://doi.org/10.1289/EHP9413 Svenja Offer,1,2Elena Hartner,1,2Sebastiano Di Bucchianico,1Christoph Bisig,1Stefanie Bauer,1Jana Pantzke,1,2Elias J. Zimmermann,1,2Xin Cao,1,2Stefanie Binder,1,2Evelyn Kuhn,1Anja Huber,1Seongho Jeong,1,2Uwe Käfer,1,2Patrick Martens,2Arunas Mesceriakovas,3Jan Bendl,1,4,5Ramona […]

February 2, 2022

LIVe 2022 – Lung in vitro event for innovative & predictive models

Lung in vitro event for innovative & predictive models After a successful first edition in 2018, LIVe2022 is back in […]

February 2, 2022

MPS World Summit 2022

Connect, Exchange, Educate Microphysiological System (MPS): cell culture systems replicating (patho)physiology through engineered organ architecture and functionality. This includes especially […]

February 2, 2022

Smoking Machine VC 10 S-TYPE for Heat-not-Burn Tobacco Devices

Now Heated Tobacco Products (HTP) can be continuously smoked with automatic button actuation. The heat-and-turn feature for heat-not-burn devices enables […]

February 2, 2022

2022 International Particulate Toxicology Conference IPTC

. The IPTC is one of the longest standing scientific meetings in its field. It started in […]

February 1, 2022

Automation and Standardization—A Coupled Approach Towards Reproducible Sample Preparation Protocols for Nanomaterial Analysis

https://doi.org/10.3390/molecules27030985 Jörg Radnik 1, Vasile-Dan Hodoroaba 1, Harald Jungnickel 2, Jutta Tentschert 2, Andreas Luch 2, Vanessa Sogne 3, Florian […]

January 19, 2022

Product News 01/2022

Online measurement of particle concentrations VITROCELL® Photometers are specifically designed and developed to enable online measurements of particle concentrations. The […]

December 9, 2021

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia

https://doi.org/10.1016/j.bbrep.2021.101187 David Bovard b, Marco van der Toorn b, Walter K. Schlage a, Samuel Constant c, Kasper Renggli b, Manuel […]

November 27, 2021

Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface

https://doi.org/10.3390/nano11123226 Sivakumar Murugadoss 1, Sonja Mülhopt 2, Silvia Diabaté 3, Manosij Ghosh 1, Hanns-Rudolf Paur 2, Dieter Stapf 2, Carsten […]

November 12, 2021

Product News 11/2021

Improved Sensor for High Precision Real-Time Dose Monitoring The VITROCELL® sQCM 12 is the next step in the evolution of dosimetry […]

October 11, 2021

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air–liquid interface in exposure concentrations relevant at workplaces

https://doi.org/10.1002/em.22464 Stephanie Binder1,2, Xin Cao1,2, Stefanie Bauer1, Narges Rastak1, Evelyn Kuhn1, George C. Dragan3, Christian Monseé4, George Ferron1, Dietmar Breuer5, […]

August 18, 2021

11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11) goes virtual

Ground-breaking virtual experience If you are interested in 3Rs science, you should consider attending the 11th World Congress on Alternatives […]

August 12, 2021

Product News 08/2021

Let us lend you a helping hand via HoloLens VITROCELL in vitro exposure systems are specifically manufactured according to customer […]

June 27, 2021

Impact of Nanocomposite Combustion Aerosols on A549 Cells and a 3D Airway Model

https://doi.org/10.3390/nano11071685 Matthias Hufnagel 1, Nadine May 2, Johanna Wall 1, Nadja Wingert 3, Manuel Garcia-Käufer 3, Ali Arif 3, Christof […]

June 21, 2021

In vitro hazard characterization of simulated aircraft cabin bleed-air contamination in lung models using an air-liquid interface (ALI) exposure system

https://doi.org/10.1016/j.envint.2021.106718 Rui-Wen He a,b, Marc M.G. Houtzager c, W.P. Jongeneel a, Remco H.S. Westerink b, Flemming R. Cassee a,b a […]

June 15, 2021

VITROCELL® Cloud Alpha - A Family of Exposure Systems Suitable for Nebulized Solutions and Suspensions

Patrick Weindl, Heidi Ortolf-Wahl, Tobias Krebs VITROCELL Systems GmbH, 79183 Waldkirch, Germany Optimal Solution for Everyday Experiments at the […]

June 2, 2021

Development of a standardized in vitro approach to evaluate microphysical, chemical, and toxicological properties of combustion-derived fine and ultrafine particles

https://doi.org/10.1016/j.jes.2021.06.001 Ana Teresa Juarez-Facio 1, Clément Castilla 2, Cécile Corbière 1, Hélène Lavanant 2, Carlos Afonso 2, Christophe Morin 2, […]

April 20, 2021

An In Vitro Air-Liquid Interface Inhalation Platform for Petroleum Substances and Constituents

DOI: 10.14573/altex.2010211 Sandra Verstraelen1, An Jacobs1, Jo Van Laer1, Karen Hollanders1, Masha Van Deun2, Diane Bertels2, Rob Brabers1, Hilda Witters1, […]

April 18, 2021

Product News 04/2021

How to use Millicell 24-well Standing Inserts in the VITROCELL® 12 Module Series The revolutionary new holder system enables for […]

March 3, 2021

Vitrocell® Leak Tester

Regular leak tests are mandatory in aerosol research. A leak caused by a forgotten connection or defective o-ring may have […]

February 23, 2021

Product News 02/2021

Reliable digital Humidity- and Temperature Measurement The VITROCELL® RH/T-Controller system was designed to measure temperature and relative humidity in numerous applications […]

February 15, 2021

Impact of Sea Breeze Dynamics on Atmospheric Pollutants and Their Toxicity in Industrial and Urban Coastal Environments

doi:10.3390/rs12040648 Patrick Augustin 1, Sylvain Billet 2 , Suzanne Crumeyrolle 3, Karine Deboudt 1, Elsa Dieudonné 1 , Pascal Flament […]

January 29, 2021

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

DOI: 10.3389/fbioe.2021.616830 Ali Doryab 1,2, Mehmet Berat Taskin 3, Philipp Stahlhut 3, Andreas Schröppel 1,2, Sezer Orak 1,2, Carola Voss […]

January 22, 2021

Product News 01/2021

Smallest nebulization volumes and high deposition efficiency The VITROCELL® Cloud Alpha MAX is designed for small nebulization volumes and very high […]

January 15, 2021

New Video: VITROCELL Cloud Alpha – Product Family Overview

The VITROCELL® Cloud Alpha series is our newest innovation and presents a great leap forward in automated exposure of cell […]

January 14, 2021

Toxic effects of gunshot fumes from different ammunitions for small arms on lung cells exposed at the air liquid interface

https://doi.org/10.1016/j.tiv.2021.105095 Espen Mariussen a,b, Lise Fjellsbø a,c, Tomas Roll Frømyr b, Ida Vaa Johnsen b, Tove Engen Karsrud b, Øyvind […]

December 29, 2020

Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects

https://doi.org/10.3390/nano11010065 Silvia Diabaté 1, Lucie Armand 2, Sivakumar Murugadoss 1 , Marco Dilger 1 , Susanne Fritsch-Decker 1, Christoph […]

December 2, 2020

Toxicological responses of BEAS-2B cells to repeated exposures to benzene, toluene, m-xylene, and mesitylene using air–liquid interface method

DOI: 10.1002/jat.4113 Clémence Méausoone1, Yann Landkocz1, Fabrice Cazier2, Marianne Seigneur1, Dominique Courcot1, Sylvain Billet1 1 Unité de Chimie Environnementale et […]

November 30, 2020

Product News 12/2020

For reliable aerosol exposure of cell cultures using 12- or 24-well sized inserts The VITROCELL® 12/12 module system has been designed […]

November 28, 2020

Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles

doi:10.3390/nano10122369 Lars B. Leibrock 1, Harald Jungnickel 1, Jutta Tentschert 1, Aaron Katz 1, Blaza Toman 2 , Elijah J. […]

November 19, 2020

Sub‑ohm vaping increases the levels of carbonyls, is cytotoxic, and alters gene expression in human bronchial epithelial cells exposed at the air–liquid interface

https://doi.org/10.1186/s12931-020-01571-1 Alexandra Noël, Ekhtear Hossain, Zakia Perveen, Hasan Zaman and Arthur L. Penn Department of Comparative Biomedical Sciences, School of […]

November 18, 2020

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

https://doi.org/10.1016/j.toxlet.2020.11.006 Albert Giralta, Anita R Iskandara, FlorianMartina, ElisaMoschinib, TomassoSerchib, AthanasiosKondylisa, DiegoMarescottia, PatriceLeroya, LauraOrtega-Torresa, ShoaibMajeeda, CelineMerga, KeyurTrivedia, EmmanuelGuedja,StefanFrentzela, Nikolai V Ivanova, Manuel […]

November 15, 2020

The Comparative Analysis of Cytokine Production by a Human 3D Tissue Model Following Exposure to Traditional Cigarette Smoke, Tobacco-Heated Product and E-Cigarette Aerosol

Rob Bedford1, Emma Rothwell1, Sophie Martin1, Cian O’Hanlon1, Andrew McCune2 and Michael Hollings1 1Genetic and Molecular Toxicology and 2Immunology and […]

November 11, 2020

Exposure of cellulose nanocrystals on human lung cells at the air-liquid-interface

Michelle Hesler1, Annika Kittel1, Stephan Dähnhardt-Pfeiffer2, Christoph Metzger3, Christine Herrmann3, Marielle Fink4, Heiko Briesen3, Tobias Krebs4, Hagen von Briesen1, Sylvia […]

November 2, 2020

Toxicological responses of BEAS-2B cells to repeated exposures to benzene, toluene, m-xylene, and mesitylene using air–liquid interface method

DOI: 10.1002/jat.4113 Clémence Méausoone1, Yann Landkocz1, Fabrice Cazier2, Marianne Seigneur1 Dominique Courcot1, Sylvain Billet1 1Unité de Chimie Environnementale et Interactions […]

November 2, 2020

Influence of the environmental relative humidity on the inflammatory response of skin model after exposure to various environmental pollutants

https://doi.org/10.1016/j.envres.2020.110350 Emeline Seurat a, Anthony Verdin b, Fabrice Cazier c, Dominique Courcot b, Richard Fitoussi d, Katell Vi´e d, Val´erie […]

October 31, 2020

Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures

https://doi.org/10.1016/j.jaerosci.2020.105703 Rui-Wen He a,b, Hedwig M. Braakhuis a, Rob J. Vandebriel a, Yvonne C.M. Staal a, Eric R. Gremmer […]

October 21, 2020

New Video: VITROCELL Cloud Alpha – for Aerosol Research and Cell Exposure at the Air/Liquid Interface (ALI)

The VITROCELL® Cloud Alpha series is our newest innovation and presents a great leap forward in automated exposure of cell […]

October 17, 2020

Cell‑specific toxicity of short‑term JUUL aerosol exposure to human bronchial epithelial cells and murine macrophages exposed at the air–liquid interface

https ://doi.org/10.1186/s1293 1-020-01539-1 Rakeysha Pinkston1,2, Hasan Zaman2, Ekhtear Hossain2, Arthur L. Penn2 and Alexandra Noël2 1 Department of Environmental Toxicology, […]

October 8, 2020

Alternative air–liquid interface method for inhalation toxicity testing of a petroleum-derived substance

https://doi.org/10.1016/j.mex.2020.101088 Verstraelen Sandra a , Jacobs An a , Van Laer Jo a , Van Deun Masha b , Bertels […]

September 29, 2020

Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives

https://doi.org/10.1007/s11626-020-00517-7 Xuefei Cao1, Jayme P. Coyle2, Rui Xiong1, Yiying Wang1, Robert H. Heflich1, Baiping Ren1, William M. Gwinn3, Patrick Hayden4, […]

September 28, 2020

NanoCELL - Comprehensive characterization and human toxicological assessment of cellulose nanocrystals along their life cycle for reliable risk assessment

Yvonne Kohl1, Roland Drexel2, Christine Herrmann3, Stephan Dähnhardt-Pfeiffer4, Siegfried Fürtauer5, Michelle Hesler1, Christoph Metzger3, Marielle Fink6, Dominik Selzer7, Thorsten Lehr7, […]

September 18, 2020

VITROCELL® Shisha Testing System for Cell Cultures

New designs of electronic cigarettes such as ENDS (Electronic Nicotine Delivery Systems) products or HTP (Heated Tobacco Products) lead to […]

September 16, 2020

Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems

https://doi.org/10.1186/s12989-020-00376-w Yaobo Ding1,2 , Patrick Weindl1,2,3, Anke-Gabriele Lenz1,2, Paula Mayer1,2, Tobias Krebs3 and Otmar Schmid1,2 1Institute of Lung Biology and […]

August 27, 2020

Comparative anti-inflammatory effect of curcumin at air-liquid interface and submerged conditions using lipopolysaccharide stimulated human lung epithelial A549 cells

https://doi.org/10.1016/j.pupt.2020.101939 Yue Hu a,b,c, Yunhua Sheng c,e, Xiaoli Ji c,e, Ping Liu c,e, Liming Tang c,e, Gang Chen a,Guiliang Chen […]

August 24, 2020

Product News 08/2020

96-well Air/Liquid Interface (ALI) exposure. For reliable high throughput testing of cell cultures. The VITROCELL® Cloud Alpha 96 is our […]

August 15, 2020

Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure

https://doi.org/10.1016/j.tiv.2020.104968 Artik Mistry, Larry E. Bowen, Michael W. Dzierlenga, Jessica K. Hartman, Scott D. Slattery ScitoVation, LLC, Durham, NC 27713, […]

July 27, 2020

Vitrocell® holder systems for e-cigarettes

New designs of electronic cigarettes such as ENDS (Electronic Nicotine Delivery Systems) products or HTP (Heated Tobacco Products) lead to […]

July 27, 2020

An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols

doi:10.3390/ijms21155335 Hana Barosova 1,2 , Bedia Begum Karakocak 1 , Dedy Septiadi 1 , Alke Petri-Fink 1,3, Vicki Stone 4 […]

July 26, 2020

Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air–liquid interface

https://doi.org/10.1016/j.tiv.2020.104950 Authors Rui-WenHeab, Miriam E.Gerlofs-Nijlanda, JohnBoerea, PaulFokkensa, DaanLesemana, Nicole A.H.Janssena, Flemming R.Casseeab a National Institute for Public Health and the […]

July 13, 2020

An experimental aerosol air–agar interface mouse lymphoma assay methodology

DOI: https://doi.org/10.1016/j.mrgentox.2020.503230 Authors Thorne D1, Hollings M2, Kilford J2, Clements J2, Payne R2, Ballantyne M2, Dalrymple, A1, Dillon, D1, Meredith, […]

June 25, 2020

Novel TEM Grid holders for dose determination of airborne particles during in vitro Exposure at the air / liquid interface

The assessment of toxicological effects of airborne particles to the human organism is of major importance in disease research. The […]

May 21, 2020

A novel TEM grid sampler for airborne particles to measure the cell culture surface dose

Sonja Mülhopt1, Christoph Schlager2, Markus Berger2, Sivakumar Murugadoss3, Peter H. Hoet3, Tobias Krebs2, Hanns-Rudolf paur1 & Dieter Stapf1 1Karlsruhe Institute […]

May 13, 2020

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

DOI:10.3791/61210 Hedwig M. Braakhuis1, Ruiwen He1,2, Rob J. Vandebriel1, Eric R. Gremmer1, Edwin Zwart1, Jolanda P. Vermeulen1, Paul Fokkens1, John […]

April 14, 2020

Toxicity and Gene Expression Profiling of Copper- and Titanium-Based Nanoparticles Using Air–Liquid Interface Exposure

https://doi.org/10.1021/acs.chemrestox.9b00489 Matthias Hufnagel, Sarah Schoch, Johanna WallBettina, Maria Strauch, Andrea Hartwig Department of Food Chemistry and Toxicology, Institute of Applied […]

March 27, 2020

Reliable in vitro Exposure Systems for Screening of Antiviral Lead Compounds against Coronavirus (COVID-19 / SARS-CoV-2)

In inhalation therapy, drugs are deposited as aerosols on cells of the respiratory tract from the nasal or lung region. […]

March 26, 2020

New lung model gives lab animals a breather

Autor Francesca Lake Source Barosova H, Maione AG, Septiadi D et al. Use of EpiAlveolar lung model to predict fibrotic […]

March 26, 2020

Screening antiviraler pharmazeutischer Leitwirkstoffe gegen das Coronavirus (COVID-19 / SARS-CoV-2)

In der Inhalationstherapie werden pharmazeutische Präparate als Aerosole auf Zellen des Atemtraktes im Nasen- oder Lungenbereich appliziert. Zur präklinischen Entwicklung […]

March 24, 2020

Comparison of Vapor and Liquid Phase Acrolein Exposures to Air Liquid Interface (ALI) Cell Cultures

David H. Brandwein, F. Adam Bettmann, Michael P. DeLorme, Alan T. Eveland, Lawrence M. Milchak 3M Corporate Toxicology and Environmental […]

March 20, 2020

Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes

https://dx.doi.org/10.1021/acsnano.9b06860 Autors Barosova H1, Maione AG2, Septiadi D1, Sharma M3, Haeni L1, Balog S1, O'Connell O2, Jackson GR2, Brown D4, […]

March 17, 2020

Product News 2020

Here you can find the latest VITROCELL developments. One highlight is the new VITROCELL Cloud Alpha series which you can […]

February 28, 2020

Lung Cell Exposure to Secondary Photochemical Aerosols Generated From OH Oxidation of Cyclic Siloxanes

DOI: 10.1016/j.chemosphere.2019.125126 Autors Benjamin M King 1 , Nathan J Janechek 1 , Nathan Bryngelson 1 , Andrea Adamcakova-Dodd 2 […]

February 25, 2020

Comparison of in vitro toxicity of aerosolized engineered nanomaterials using air-liquid interface mono-culture and co-culture models

https://doi.org/10.1016/j.impact.2020.100215 Autors Yifang Wanga, Andrea,Adamcakova-Doddb, Benjamin R.Steinesb, Xuefang Jingb, Aliasger K.Salemc, Peter S.Thorneab a Human Toxicology Interdisciplinary Program, University of […]

February 24, 2020

In vitro advances in whole aerosol approaches for e-cigarette testing

Autor David Thorne, British American Tobacco Workshop series to identify, discuss and develop recommendations for the optimal generation and […]

February 19, 2020

Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cellcultures

doi: 10.1016/j.tiv.2020.104798 Autors Medina-Reyes EI1, Delgado-Buenrostro NL2, Leseman DL3, Déciga-Alcaraz A2, He R4, Gremmer ER3, Fokkens PHB3, Flores-Flores JO5, Cassee […]

January 15, 2020

Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward.

https://doi.org/10.1016/j.mrgentox.2020.503135 Authors StefanPfuhlera, Janvan Benthemb, RodgerCurrenc, Shareen H.Doakd, MariaDusinskae, MakotoHayashif, Robert H.Heflichg, DarrenKiddh, DavidKirklandi, YangLuanj, GladysOuedraogok, KerstinReisingerl, ToshioSofunim, Frédériquevan Ackern, […]

December 31, 2019

High Throughput Air Liquid Interface Exposure Modules: Characterization of Smoke/Aerosol Dosimetry and in vitro Mutagenicity and Cytotoxicity of Two Tobacco Product Types

Robert Leverette1, Brian Keyser1, Michael Hollings2 and Adam Seymour2 1RAI Services Company, Winston−Salem, NC 27101 USA 2Covance Laboratories Ltd., Harrogate, […]

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