News & Publications

November 10, 2023

In vitro lung cell exposure at the air-liquid interface shows significant increase in publications.

Indicating a shift from animal testing towards alternative methods. Sonja Mülhopt from our cooperation partner, the Karlsruhe Institute of Technology […]

October 29, 2023

Inhalation toxicity of thermal transformation products formed from e-cigarette vehicle liquid using an in vitro lung model exposed at the Air–Liquid Interface

https://doi.org/10.1016/j.fct.2023.114157 T. Ruth a, J. Daniel b, A. Konig a, R. Trittler c, M. Garcia-Kaufer aa Institute for Infection Prevention […]

October 17, 2023

Society of Toxicology’s 63rd Annual Meeting and ToxExpo

SOT is returning to Salt Lake City for the first time in more than a decade for its 63rd Annual […]

October 10, 2023

Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells

https://doi.org/10.3390/toxics11100847 Gianni Zarcone , Marie Lenski , Thomas Martinez, Smaïl Talahari, Ophélie Simonin, Guillaume Garçon, Delphine Allorge, Fabrice Nesslany, Jean-Marc […]

October 8, 2023

In vitro micronucleus in V79 cells using MicroFlow® – Treatment at the air liquid interface with aerosol from three different nicotine containing products

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Emma Rothwell, Gina Smith, Sophie Martin and Michael Hollings;Labcorp Early Development Laboratories Ltd., […]

October 8, 2023

In vitro cytotoxicity and mechanistic insight from MucilAir™ and SmallAir™ tissues exposed to cigarette smoke and next-generation products

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Hollings, M1; Rothwell E1; Martin S1; Daunt, A1; Freiberg, G2; Bedford, R1;Labcorp Early […]

October 8, 2023

Validation of the Vitrocell® HTP 2.0+ 12-well mammalian module for assessing cigarettes, ENDS and eHTPs: Evaluation of dilution airflow, dose resolution and dose repeatability

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Adam Seymour, Emma Rothwell, Sophie Martin and Michael Hollings;Labcorp Early Development Laboratories Ltd., […]

September 28, 2023

A multi-organ, lung-derived inflammatory response following in vitro airway exposure to cigarette smoke and next-generation nicotine delivery products

https://doi.org/10.1016/j.toxlet.2023.09.010 R. Bedford a, G. Smith a, E. Rothwell a, S. Martin a, R. Medhane a, D. Casentieri a, A. […]

September 25, 2023

VITROCELL at the CORESTA Conference of the Smoke Science and Product Technology Sub-Groups (SSPT2023), 08-12 October 2023

++++++++++ REVIEW: Sunrise for NAMs NAMs (New Approach Methods) are in vitro and in silico or computational-based methodologies in toxicology […]

September 14, 2023

VITROCELL with Cloud Alpha and PowderX at the 57th Congress of the European Societies of Toxicology (EUROTOX), September 10-13, 2023

++++++++++ REVIEW: We had a fantastic time at EUROTOX 2023! VITROCELL displayed the latest Cloud Alpha Devices: Cloud Alpha 12, […]

September 7, 2023

Filling the gaps: A lung-on-chip for R&D and preclinical studies

G. Raggi1, Lea de Maddalena1, Laurène Froment1, Nicole Albrecher1, Arunima Sengupta2,3, Andreas Hugi1, Léa Todeschini1, Janick D. Stucki1, and Nina […]

September 1, 2023

VITROCELL with Cloud Alpha AX12 and Cloud Alpha 12 at the 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12), August 27-31, 2023

++++++++++ Review: We had a great time at WC12! We send a cordial thank you to Dr. Nina Hobi from […]

September 1, 2023

VITROCELL with Cloud Alpha and PowderX at the 24th ISAM Congress, August 26-30, 2023

++++++++++ REVIEW: We had a great time at ISAM 2023! VITROCELL showcased the latest Cloud Alpha Devices: Cloud Alpha 12, […]

August 31, 2023

Product News 08/2023: New VITROCELL® 96-well HTS

The VITROCELL® 96 Exposure System has been specifically designed and engineered to facilitate the research of human cell cultures in […]

August 26, 2023

Monitoring diesel exhaust particles deposition on lung cells in vitro by lock-in thermography

ISAM Congress 2023 – August 26-30, Saarbrücken, Germany Ruiwen He a, Olivier Schaub c, Christoph Geers c, Gowsinth Gunasingam a, […]

August 24, 2023

Systems toxicology of complex wood combustion aerosol reveals gaseous carbonyl compounds as critical constituents

https://doi.org/10.1016/j.envint.2023.108169 Marco Dilger a,b, Olivier Armant b,c, Larissa Ramme a,b, Sonja Mülhopt a,d, Sean C. Sapcariu a,e, Christoph Schlager a,d, […]

July 4, 2023

Aerosol exposure to lung-on-chip with the VITROCELL Cloud Alpha AlveoliX AX12 at 2nd MPS World Summit, June 26-30

The “2023 World Summit for Microphysiological Systems” (MPS) had a record attendence with over 1,200 participants from all over the […]

June 30, 2023

A breathing lung-on-chip model of alveolar inflammation illustrating human drug response

Poster MPS Berlin 2023 Clémentine Richter1,2, Patrick Carius1,2, Daria Harig1,2, Nuria Roldan3, Janick Stucki3, Nina Hobi3, Tobias Krebs4, Brigitta Loretz1, […]

June 26, 2023

Product News 06/2023: Exposure of Lung Cells to Liquid Aerosols at the Air/Liquid Interface: New VITROCELL® Cloud Alpha TRIO

Good Things Come in Threes: This latest member of the Cloud Alpha family features the delivery of three different aerosol […]

June 16, 2023

VITROCELL® V-CARE Service

At VITROCELL®, exceptional customer service is the foundation of our customer relationships. We have now taken a step further by […]

May 18, 2023

Transferability and reproducibility of exposed air-liquid interface co-culture lung models

https://doi.org/10.1016/j.impact.2023.100466 Hedwig M. Braakhuis a, Eric R. Gremmer a, Anne Bannuscher b, Barbara Drasler b, Sandeep Keshavan b, Barbara Rothen-Rutishauser […]

May 10, 2023

2nd MPS World Summit, Booth 53, June 26-30, 2023

The MPS World Summit, organized by the Johns Hopkins Center for Alternatives to Animal Testing (CAAT) and EUROoCS, with the […]

May 10, 2023

Method development of a waterpipe aerosol exposure system for in vitro testing using 3D reconstructed human airway tissue

Jeremie Gafner , Christelle Lamboley , Louise NeilsonJT International SA, Scientific & Regulatory Affairs, Geneva, Switzerland The study’s objective was […]

April 6, 2023

10th NanOEH Conference

In 2023, two internationally renowned conferences, Inhaled Particles and NanOEH are coming together to disseminate the current knowledge and understanding […]

March 20, 2023

Product News 03/2023

Please see our latest product improvements and developments, such as the 24/48 Exposure System, the PowderX for dry powder exposure […]

March 19, 2023

Human cell-based in vitro systems to assess respiratory toxicity: A case study using silanes

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Monita Sharma1, Andreas O. Stucki1, Sandra Verstraelen2, An […]

March 19, 2023

Cytotoxicity Assessment of Heated Tobacco Product and Combustible Cigarette Aerosols Utilizing Whole Aerosol Exposure in the Neutral Red Uptake Assay

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Robert Leverette1, Thomas Shutsky1, Rebecca Payne2, Kristen Jordan1 […]

March 19, 2023

Nrf2 Responses in a 3D Human Airway Model Exposed to Whole Aerosol from Combustible Cigarettes or Heated Tobacco Products

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Brian M. Keyser1, John Wertman1, Michael Hollings2, Kristen […]

March 19, 2023

Non-Combustible Next Generation Products induce lower toxiscity than Combustible Tobacco in an Alveolar-Immune coculture model

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Matthew Stevenson1, Ewelina Hoffmann2, Abigail Martin2, Edgar Trelles […]

March 19, 2023

Non-combustible Next Generation Products induce lower biological activity than combustible tobacco on a human cardiovascular model on-a-chip

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Fiona Chapman1, Luuk de Haan2, Linda Gijzen2, Edgar […]

March 19, 2023

Method Development to Establish and Characterize an Air Liquid Interface (ALI) Exposure System Using Perfluorooctanoic Acid (PFOA) Liquid Aerosol

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Amit Gupta, Bob Moyer, Stephanie Pearson, William Puerner, […]

March 19, 2023

Filling the gaps: translating lung in vitro toxicology

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA Nuria Roldan1, G. Raggi1, Lea de Maddalena1, Arunima […]

March 16, 2023

Biological impact of sequential exposures to allergens and ultrafine particle-rich combustion aerosol on human bronchial epithelial BEAS-2B cells at the air liquid interface

doi: 10.1002/jat.4458 Elias Josef Zimmermann 1 2, Joana Candeias 3, Nadine Gawlitta 1, Christoph Bisig 1, Stephanie Binder 1 2, […]

March 15, 2023

Development and Characterization of a 96-Well Exposure System for Safety Assessment of Nanomaterials

DOI: 10.1002/smll.202207207 Yvonne Kohl1, Michelle Müller1, Marielle Fink2, Marc Mamier2, Siegfried Fürtauer3, Roland Drexel4, Christine Herrmann5, Stephan Dähnhardt-Pfeiffer6, Ramona Hornberger3, […]

March 11, 2023

Evaluation of the cytotoxic and genotoxic potential of printer toner particles in a 3D air-liquid interface, primary cell-based nasal tissue model

DOI: 10.1002/jat.3038 Till Jasper Meyer a, Nursen Tekin a, Peter Hense b, Totta Ehret-Kasemo a, Nina Lodes c, Manuel Stöth […]

March 9, 2023

Society of Toxicology’s 62nd Annual Meeting and ToxExpo

Taking place in Nashville, Tennessee, the SOT 62nd Annual Meeting and ToxExpo will feature more than 70 Featured and Scientific […]

March 6, 2023

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

doi: 10.3389/fphar.2023.1114739 Arunima Sengupta 1, Aurélien Dorn 1,2, Mohammad Jamshidi 1, Magali Schwob1, Widad Hassan 1, Lea Lara De Maddalena […]

February 15, 2023

Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts

https://doi.org/10.1016/j.etap.2023.104079 Jana Pantzke a,b, Arne Koch a, Elias J. Zimmermann a,b, Narges Rastak b, Svenja Offer a,b, Christoph Bisig b, […]

January 19, 2023

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

DOI: 10.3390/nano13030407 Elisabeth Elje 1,2,Espen Mariussen 1,3,Erin McFadden 1,Maria Dusinska 1 and Elise Rundén-Pran 1,1 Health Effects Laboratory, Department for […]

January 19, 2023

2023 User Group Meeting

We wish to invite you to participate at our User Group Meeting 2023, an excellent opportunity to discuss our latest […]

January 18, 2023

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

https://doi.org/10.3390/ijms24031927 Alexandra Friesen 1, Susanne Fritsch-Decker 2, Sonja Mülhopt 3 , Caroline Quarz 1, Jonathan Mahl 3, Werner Baumann 3, […]

December 14, 2022

Carbonyl Profiles of Electronic Nicotine Delivery System (ENDS) Aerosols Reflect Both the Chemical Composition and the Numbers of E-Liquid Ingredients–Focus on the In Vitro Toxicity of Strawberry and Vanilla Flavors

https://doi.org/10.3390/ijerph192416774 Alexandra Noël and Arpita GhoshDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA […]

November 18, 2022

Rescue of Ciliary Function in Cell-based Primary Ciliary Dyskinesia Models using Nebulized, LNP-formulated mRNA

Rumpa B. Bhattacharjee1, Mirko Hennig1, Daniella Ishimaru1, David Liston1, Jackson K. Eby2, Christian C. Corona1, Ishita Agarwal1 Jade E. Casillas1, […]

November 14, 2022

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

https://doi.org/10.1016/j.impact.2022.100439 Anne Bannuscher a, Otmar Schmid b,c, Barbara Drasler a, Alain Rohrbasser a, Hedwig M. Braakhuis d, Kirsty Meldrum e, Edwin […]

November 3, 2022

Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell® Mammalian 6/48 exposure module

https://doi.org/10.1016/j.toxrep.2022.11.001 Brian M. Keyser1, Robert Leverette1, Michael Hollings2, Adam Seymour2, Randy A. Weidman3, Carlton J. Bequette3, Kristen Jordan1 1 RAI […]

October 28, 2022

ESTIV 2022 – International Congress of the European Society of Toxicology In Vitro

VITROCELL will participate in the 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022), held […]

October 27, 2022

VITROCELL® sQCM 12: Data Interpretation

The Quartz Crystal Microbalance is a powerful tool for dosimetry in VITROCELL Exposure Systems. However, interpreting live-data from a sQCM […]

October 13, 2022

Toxicological impact of organic ultrafine particles (UFPs) in human bronchial epithelial BEAS-2B cells at air-liquid interface

https://doi.org/10.1016/j.tiv.2021.105258 A. T. Juarez Facio1, J. Yon2, C. Corbière1, T. Rogez-Florent1, C. Castilla3, H. Lavanant3, M. Mignot3, C. Devouge-Boyer3, C. […]

September 30, 2022

NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene

https://doi.org/10.1016/j.tox.2022.153340 Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen, Scott D. Slattery […]

September 30, 2022

Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

https://doi.org/10.3390/nano12193431 Kirsty Meldrum, Joana A. Moura, Shareen H. Doak and Martin J. D. Clift In Vitro Toxicology Group, Swansea University […]

September 26, 2022

Product News 06-9/2022

For fully automated and repeated row-by-row exposure of 12-, 24- and 96-well sized cell culture inserts. Testing of up to […]

September 9, 2022

ICT 2022 – International Congress of Toxicology

After an intensive preparation period, it is with great pleasure that the Dutch Society of Toxicology (NVT) is welcoming […]

August 22, 2022

Carbon nanoparticles adversely affect CFTR expression and toxicologically relevant pathways

https://doi.org/10.1038/s41598-022-18098-8 Torben Stermann1, Thach Nguyen1, Burkhard Stahlmecke2, Ana Maria Todea2, Selina Woeste1, Inken Hacheney1, Jean Krutmann1,3, Klaus Unfried1, Roel P. […]

July 29, 2022

Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures

https://doi.org/10.3390/nano12152609 Laura Maria Azzurra Camassa 1, Elisabeth Elje 2,3, Espen Mariussen 2,4, Eleonora Marta Longhin 2, Maria Dusinska 2, Shan […]

June 21, 2022

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

https://doi.org/10.1016/j.envint.2022.107366 Michal Pardoa, Svenja Offerbc, Elena Hartnerbc, Sebastiano Di Bucchianicob, Christoph Bisigb, Stefanie Bauerb, Jana Pantzkebc, Elias J. Zimmermannbc, XinCaobc, […]

June 15, 2022

Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48

DOI: 10.1089/aivt.2022.0001 Brian M. Keyser,1 Robert Leverette,1 Michael Hollings,2 Adam Seymour,2 Randy J. Weidman,3 Carlton J. Bequette,3 and Kristen Jordan1 […]

June 1, 2022

Product News 05-4/2022

For cell culture exposure to smallest quantities of dry powders The VITROCELL® PowderX allows for aerosolisation of small quantities of […]

April 15, 2022

Aerosol–Cell Exposure System Applied to Semi-Adherent Cells for Aerosolization of Lung Surfactant and Nanoparticles Followed by High Quality RNA Extraction

https://doi.org/10.3390/nano12081362 Mélanie M. Leroux 1 , Romain Hocquel 1, Kevin Bourge 1 , Boštjan Kokot 2 , Hana Kokot 2 […]

April 11, 2022

Product News 04-3/2022

Aerosol exposure for breathing AX Lung-on-Chip The VITROCELL® Cloud Alpha AX12 is our newest innovation in the Cloud family and […]

April 6, 2022

Product News 04-2/2022

Manual smoking machine with high tech features The VC 1 smoking machine is used for a controlled aerosol generation of […]

April 4, 2022

Product News 04-1/2022

Increase of nebulizations and evacuation of residual gaseous compounds A typical Cloud exposure allows 3 consecutive nebulizations. The PowerVent option […]

March 27, 2022

Nrf2 Responses of Commercial Cigarette Whole Smoke and Aerosol from Six Electronic Nicotine Delivery Systems (ENDS) in a 3D Human Airway Model

Brian M. Keyser1, John Wertman1, Michael Hollings2, Robert Bedford2, and Kristen Jordan1 1 Scientific & Regulatory Affairs, RAI Services Company, […]

March 27, 2022

Cytotoxicity Assessment of Electronic Nicotine Delivery Systems (ENDS) and Combustible Cigarette Aerosols Utilizing Standard and Whole Aerosol Exposure Approaches in the Neutral Red Uptake Assay

Robert Leverette1, Thomas Shutsky1, John Wertman1, Katarina Aleksa2, Dhatri Lakshmanan2, Rebecca Payne3, Kristen Jordan1 1Scientific & Regulatory Affairs, RAI Services […]

March 27, 2022

In Vitro Cytotoxicity Assessment of 3D Human Airway Tissue Following Exposure to Whole Aerosol/Smoke Generated from Electronic and Combustible Cigarettes

Thomas Shutsky1, Brian M. Keyser1, Kristen Jordan1, Michael Hollings2, and Emma Rothwell2 1Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, […]

March 22, 2022

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium

https://doi.org/10.1172/jci.insight.155589 Kristine M. Abo,1,2 Julio Sainz de Aja,3,4,5 Jonathan Lindstrom-Vautrin,1 Konstantinos-Dionysios Alysandratos,1,2 Alexsia Richards,6 Carolina Garcia-de-Alba,3,4,5 Jessie Huang,1,2 Olivia T. […]

March 18, 2022

Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol

https://doi.org/10.1016/j.tiv.2022.105352 J. Zhang1, U. Doshi1, R.L. Wolz2, P. Kosachevsky2, M.J. Oldham1,2, I.G. Gillman2,2 , K.M. Lee1 1Altria Client Services LLC, […]

March 1, 2022

The priming effect of diesel exhaust on native pollen exposure at the air-liquid interface

https://doi.org/10.1016/j.envres.2022.112968 Joana Candeiasa, Elias J. Zimmermannbc, Christoph Bisigb, Nadine Gawlittabc, Sebastian Oederb, Thomas Grögerb, Ralf Zimmermannbc, Carsten B. Schmidt-Webera, Jeroen […]

February 7, 2022

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

Aditya R. Kolli, 1 Tanja Zivkovic Semren, 1 David Bovard, 1 Shoaib Majeed, 1 Marco van der Toorn, 1 Sophie […]

February 3, 2022

Product News 02-1/2022

For liquid droplet sizes 9 – 12 μm with diffusor Certain chemicals or formulations, for example nasal sprays, often have […]

February 3, 2022

Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs

https://doi.org/10.1289/EHP9413 Svenja Offer,1,2Elena Hartner,1,2Sebastiano Di Bucchianico,1Christoph Bisig,1Stefanie Bauer,1Jana Pantzke,1,2Elias J. Zimmermann,1,2Xin Cao,1,2Stefanie Binder,1,2Evelyn Kuhn,1Anja Huber,1Seongho Jeong,1,2Uwe Käfer,1,2Patrick Martens,2Arunas Mesceriakovas,3Jan Bendl,1,4,5Ramona […]

February 2, 2022

LIVe 2022 – Lung in vitro event for innovative & predictive models

Lung in vitro event for innovative & predictive models After a successful first edition in 2018, LIVe2022 is back in […]

February 2, 2022

MPS World Summit 2022

Connect, Exchange, Educate Microphysiological System (MPS): cell culture systems replicating (patho)physiology through engineered organ architecture and functionality. This includes especially […]

February 2, 2022

Smoking Machine VC 10 S-TYPE for Heat-not-Burn Tobacco Devices

Now Heated Tobacco Products (HTP) can be continuously smoked with automatic button actuation. The heat-and-turn feature for heat-not-burn devices enables […]

February 2, 2022

2022 International Particulate Toxicology Conference IPTC

The IPTC is one of the longest standing scientific meetings in its field. It started in the UK in 1979 […]

February 1, 2022

Automation and Standardization—A Coupled Approach Towards Reproducible Sample Preparation Protocols for Nanomaterial Analysis

https://doi.org/10.3390/molecules27030985 Jörg Radnik 1, Vasile-Dan Hodoroaba 1, Harald Jungnickel 2, Jutta Tentschert 2, Andreas Luch 2, Vanessa Sogne 3, Florian […]

January 19, 2022

Product News 01/2022

Online measurement of particle concentrations VITROCELL® Photometers are specifically designed and developed to enable online measurements of particle concentrations. The […]

December 9, 2021

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia

https://doi.org/10.1016/j.bbrep.2021.101187 David Bovard b, Marco van der Toorn b, Walter K. Schlage a, Samuel Constant c, Kasper Renggli b, Manuel […]

November 27, 2021

Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface

https://doi.org/10.3390/nano11123226 Sivakumar Murugadoss 1, Sonja Mülhopt 2, Silvia Diabaté 3, Manosij Ghosh 1, Hanns-Rudolf Paur 2, Dieter Stapf 2, Carsten […]

November 26, 2021

Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation

DOI: 10.1177/02611929211061884 Vivek Patel1, Khalid Amin2, David Allen3, Lindsey Ukishima1, Adam Wahab1, Chad Grodi1 and Holger Behrsing1 1Respiratory Toxicology, Institute […]

November 12, 2021

Product News 11/2021

Improved Sensor for High Precision Real-Time Dose Monitoring The VITROCELL® sQCM 12 is the next step in the evolution of dosimetry […]

October 11, 2021

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air–liquid interface in exposure concentrations relevant at workplaces

https://doi.org/10.1002/em.22464 Stephanie Binder1,2, Xin Cao1,2, Stefanie Bauer1, Narges Rastak1, Evelyn Kuhn1, George C. Dragan3, Christian Monseé4, George Ferron1, Dietmar Breuer5, […]

August 18, 2021

11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11) goes virtual

Ground-breaking virtual experience If you are interested in 3Rs science, you should consider attending the 11th World Congress on Alternatives […]

August 12, 2021

Product News 08/2021

Let us lend you a helping hand via HoloLens VITROCELL in vitro exposure systems are specifically manufactured according to customer […]

June 27, 2021

Impact of Nanocomposite Combustion Aerosols on A549 Cells and a 3D Airway Model

https://doi.org/10.3390/nano11071685 Matthias Hufnagel 1, Nadine May 2, Johanna Wall 1, Nadja Wingert 3, Manuel Garcia-Käufer 3, Ali Arif 3, Christof […]

June 21, 2021

In vitro hazard characterization of simulated aircraft cabin bleed-air contamination in lung models using an air-liquid interface (ALI) exposure system

https://doi.org/10.1016/j.envint.2021.106718 Rui-Wen He a,b, Marc M.G. Houtzager c, W.P. Jongeneel a, Remco H.S. Westerink b, Flemming R. Cassee a,b a […]

June 15, 2021

VITROCELL® Cloud Alpha – A Family of Exposure Systems Suitable for Nebulized Solutions and Suspensions

Patrick Weindl, Heidi Ortolf-Wahl, Tobias Krebs VITROCELL Systems GmbH, 79183 Waldkirch, Germany Optimal Solution for Everyday Experiments at the Air/Liquid […]

June 2, 2021

Development of a standardized in vitro approach to evaluate microphysical, chemical, and toxicological properties of combustion-derived fine and ultrafine particles

https://doi.org/10.1016/j.jes.2021.06.001 Ana Teresa Juarez-Facio 1, Clément Castilla 2, Cécile Corbière 1, Hélène Lavanant 2, Carlos Afonso 2, Christophe Morin 2, […]

April 20, 2021

An In Vitro Air-Liquid Interface Inhalation Platform for Petroleum Substances and Constituents

DOI: 10.14573/altex.2010211 Sandra Verstraelen1, An Jacobs1, Jo Van Laer1, Karen Hollanders1, Masha Van Deun2, Diane Bertels2, Rob Brabers1, Hilda Witters1, […]

April 18, 2021

Product News 04/2021

How to use Millicell 24-well Standing Inserts in the VITROCELL® 12 Module Series The revolutionary new holder system enables for […]

March 3, 2021

Vitrocell® Leak Tester

Regular leak tests are mandatory in aerosol research. A leak caused by a forgotten connection or defective o-ring may have […]

February 23, 2021

Product News 02/2021

Reliable digital Humidity- and Temperature Measurement The VITROCELL® RH/T-Controller system was designed to measure temperature and relative humidity in numerous applications […]

February 15, 2021

Impact of Sea Breeze Dynamics on Atmospheric Pollutants and Their Toxicity in Industrial and Urban Coastal Environments

doi:10.3390/rs12040648 Patrick Augustin 1, Sylvain Billet 2 , Suzanne Crumeyrolle 3, Karine Deboudt 1, Elsa Dieudonné 1 , Pascal Flament […]

January 29, 2021

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

DOI: 10.3389/fbioe.2021.616830 Ali Doryab 1,2, Mehmet Berat Taskin 3, Philipp Stahlhut 3, Andreas Schröppel 1,2, Sezer Orak 1,2, Carola Voss […]

January 22, 2021

Product News 01/2021

Smallest nebulization volumes and high deposition efficiency The VITROCELL® Cloud Alpha MAX is designed for small nebulization volumes and very high […]

January 15, 2021

New Video: VITROCELL Cloud Alpha – Product Family Overview

The VITROCELL® Cloud Alpha series is our newest innovation and presents a great leap forward in automated exposure of cell […]

January 14, 2021

Toxic effects of gunshot fumes from different ammunitions for small arms on lung cells exposed at the air liquid interface

https://doi.org/10.1016/j.tiv.2021.105095 Espen Mariussen a,b, Lise Fjellsbø a,c, Tomas Roll Frømyr b, Ida Vaa Johnsen b, Tove Engen Karsrud b, Øyvind […]

December 29, 2020

Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects

https://doi.org/10.3390/nano11010065 Silvia Diabaté 1, Lucie Armand 2, Sivakumar Murugadoss 1 , Marco Dilger 1 , Susanne Fritsch-Decker 1, Christoph […]

December 2, 2020

Toxicological responses of BEAS-2B cells to repeated exposures to benzene, toluene, m-xylene, and mesitylene using air–liquid interface method

DOI: 10.1002/jat.4113 Clémence Méausoone1, Yann Landkocz1, Fabrice Cazier2, Marianne Seigneur1, Dominique Courcot1, Sylvain Billet1 1 Unité de Chimie Environnementale et […]

November 30, 2020

Product News 12/2020

For reliable aerosol exposure of cell cultures using 12- or 24-well sized inserts The VITROCELL® 12/12 module system has been designed […]

November 28, 2020

Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles

doi:10.3390/nano10122369 Lars B. Leibrock 1, Harald Jungnickel 1, Jutta Tentschert 1, Aaron Katz 1, Blaza Toman 2 , Elijah J. […]

1 2 3 … 5 Next »