News & Publications

August 15, 2025

In vitro toxicological evaluation of nicotine concentration and flavor variants of Vuse Alto ENDS

https://doi.org/10.1016/j.fct.2025.115640 Brian M. Keyser, Robert Leverette , Reagan McRae, John Wertman , Tom Shutsky,Kristen G. Jordan , Ken Szeliga , […]

August 15, 2025

Assessing the toxicity of traffic-derived air pollution using a primary human air-liquid interface airway in vitro model

https://doi.org/10.1016/j.envres.2025.122399 Gerrit Bredeck a, Tina Wahle a, Angela A.M. Kämpfer a, Jochen Dobner a, A. John F. Boere b, Paul Fokkens b, Evert Duistermaat b, Tim Spannbrucker a, Andrea Rossi a, Flemming R. Cassee bc, Roel P.F. Schins ad a IUF – Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 […]

Novel Groundbreaking technology for real-time tracking of particle deposition

We are proud to share the first publication introducing CalorQuanti as a groundbreaking technology for real-time tracking of particle […]

An Online Measurement Approach to Monitor the Deposition of Diesel Exhaust Particles on Lung Cells In Vitro

https://doi.org/10.1021/acs.est.4c08426 Ruiwen He1, Olivier Schaub2, Christoph Geers2, Aura Maria Moreno-Echeverri1, Gowsinth Gunasingam1, Sandor Balog1, Maik Schultheiß3, Bastian Gutmann3, Tobias Krebs3, […]

Alterations in Secreted Biomarkers Induced by Exposure of Air-Liquid Interface (ALI) Airway Tissues to 2,3-Pentanedione Vapor

Poster: AIT – Association of Inhalation Toxicologists Conference, June 3-5 2025, Milton Keynes, United Kingdom WM Gwinn1, GK Roberts1, P-L […]

Characterisation of an in vitro air-liquid interface (ALI) Inhalation exposure system.

Poster: AIT – Association of Inhalation Toxicologists Conference, June 3-5 2025, Milton Keynes, United Kingdom Matthew Sheavyn, Victoria PackHuman and […]

The efficiency of EURO 6d car particulate filters is compromised by atmospheric aging: In vitro toxicity of gasoline car exhaust

DOI: 10.1126/sciadv.adq2348 Mathilde N. Delaval1, Hendryk Czech1,2, Mohammad Almasaleekh1,2, Svenja Offer1,2, Jana Pantzke1,2, Mika Ihalainen3, Pasi Yli-Pirilä3, Markus Somero3, Miika […]

A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure

DOI: 10.1038/s41598-025-00438-z Arunima Sengupta 1 2, Saskia Schmid 3 4, Noémie Grangier 4, Aurélien Dorn 3 4, Marco Hebestreit 5, […]

Toxicological Response of the BEAS-2B Cell After Acute Exposure at the Air–Liquid Interface to Ethylbenzene and m-Xylene Alone and in Binary Mixtures

https://doi.org/10.1002/jat.4806 Nour Jaber1, Claude Emond2, Fabrice Cazier3, Sylvain Billet21UR4492, Unité de Chimie Environnementale et Interactions sur le Vivant, Université du […]

Advanced in vitro systems available for respiratory toxicology

Book Capter: Reference Module in Biomedical Sciences, 2025 https://doi.org/10.1016/B978-0-323-95488-4.00223-0 Arno C Gutleb, INVITROLIZE, Wellenstein, LuxembourgHolger P Behrsing, Institute for In […]

Development of the in vitro micronucleus test for exposure to whole aerosol from cigarettes and heated tobacco products

Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida. I. Crooks1, D. Thorne1, R. Leverette2, M. Hollings3, […]

Acute Toxicity of 1,3-Butadiene Exposure at the Air-Liquid Interface of Human Bronchial Epithelial Cells

Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida. Breandon Taylor1, Alexandra Noël2, Daniel Conklin1, and Sanjay […]

Characterization of the Aerosol Dose Uniformity in the 56-well Vitrocell® 48-2.0 Plus Exposure Module

Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida. Authors; M. J. Scian1, L. E. McFadden1, C.M. […]

Toxicity assessment of PM2.5 brake wear emissions using aerosol-based exposure models with A549-HMEC cell co-culture

Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida. Preliminary test of toxicological responce of brake wear […]

February 24, 2025

Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model

https://doi.org/10.1002/em.70000 Yuan Le1, Baiping Ren1, Levan Muskhelishvili2, Kelly Davis2, Yiying Wang1, William Gwinn3, Diego Rua4, Robert H. Heflich1, Xuefei Cao11Division […]

February 11, 2025

Evaluation of the toxicity of combustion smokes at the air-liquid interface: a comparison between two lung cell models and two exposure methods

DOI: 10.1007/s00204-025-03964-x A Ashrin 1, E Anna 1, E Peyret 1, G Barbier 1, Maxime Floreani 1, C Pointart 2, […]

February 5, 2025

Impact of waste origin and post-treatment techniques on the composition and toxicity of biogas

Carole Tanios a b c, Sylvain Billet a, Clémence Méausoone a, Yann Landkocz a, Cédric Gennequin a, Madona Labaki b, […]

January 24, 2025

Regulatory authorities recommend VITROCELL Modules for skin exposure to volatile chemicals and liquids

The Science Advisory Committee on Chemicals (SACC) of the US Environmental Protection Agency (EPA) has recently recommended the VITROCELL Skin […]

January 2, 2025

Research review and transcriptomic insights into Benzalkonium Chloride inhalation and disease association

https://doi.org/10.1016/j.ecoenv.2024.117610 Jun Woo Kim a, Min Seok Kim a, Ha Ryong Kim ba Center for Respiratory Safety Research, Korea Institute […]

January 2, 2025

Toxicological effects of long-term continuous exposure to ambient air on human bronchial epithelial Calu-3 cells exposed at the air-liquid interface

https://doi.org/10.1016/j.envres.2025.120759 E.J. Zimmermann a b, A. Das a b, A. Huber a b, N. Gawlitta a, E. Kuhn a, C. […]

December 17, 2024

Application of the market-ready NAVETTA electrodeposition chamber for controlled in vitro exposure with nano-scaled aerosols

https://doi.org/10.1016/j.csbj.2024.12.008 Magdalena Weiss a, Benjamin Punz a, Jo Van Laer b, An Jacobs b, Sylvie Remy b, Lisa Kleon a, […]

November 27, 2024

Peer Review of the 2024 Draft Risk Evaluation for 1,1-Dichloroethane and Draft Human Health Hazard Assessment for 1,2-Dichloroethane

Science Advisory Committee on Chemicals MeetingSeptember 17 to 19, 2024 Docket (EPA-HQ-OPPT-2024-0114) Alie Muneer A Set of Scientific Issues Being […]

October 22, 2024

Press Release: Collaborative Breakthrough in Lung-on-Chip Technology

Collaborative Breakthrough in Lung-on-Chip Technology: AlveoliX, VITROCELL, University of Bern and Helmholtz Institute for Pharmaceutical Research Saarland Drive Advances in […]

October 17, 2024

Quantitative AOP modeling of mucus hypersecretion using 3D cells for comparative risk estimation of heated tobacco product andcombustible cigarette

CORESTA Congress, 13-17 October 2024, Edinburgh, Scotland – UK Shigeaki Ito, Sakuya Ichikawa, Kazuo Erami, Akina Mori, Shugo Muratani, Keigo […]

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