New Products at VITROCELL® User Group Meeting 2019
March 10, 2019
Following the VITROCELL® User Group Meeting 2018 in San Antonio, Texas, USA, international scientists from Europe, Japan, Korea and USA reconvened in March 2019.
The informal event organized into short presentations and posters was followed by open discussions. It was an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange your experience in working with the equipment and to meet other fellow researchers.
The meeting took place prior to the international Society of Toxicology 58th Annual Meeting and ToxExpo, March 10 – 14, 2018, in Baltimore, USA - one of the largest international conferences related to toxicology.
Focus of the event was to share VITROCELL® activities since the last meeting, to exchange latest research results, to give an update on VITROCELL’s participation in major research programs as well as the presentation of new products for 2019.
Update on validation of the VITROCELL® 24/48 and AMES 48 exposure systems:
7 doses @ 6 replicates plus one clean air control @ 6 replicates.
Versatile 5-channel linear smoking machine VITROCELL® VC 1 S-TYPE:
for chemical characterization and in vitro testing of electronic and combustion cigarettes as well as next generation products (NGP).
VITROCELL® Powder Atomizer:
for aerosolization of dry powders
Flow Control Software:
for setting and monitoring of flow controllers for dilution air flow
New VITROCELL® Cloud Systems
VITROCELL® Cloud PowerVent and Cloud MAX:
for evacuation of residual gaseous compounds and nebulization of smallest volumes
VITROCELL® Holder System for e-cigarettes:
Secure and tight connection of any puff-actuated device to Smoking Machine
Media Inserts for VITROCELL® Exposure Modules 6 & 12 Series:
Integration of the AlveoliX Lung-on-Chip into VITROCELL® exposure Systems
Utilization of a human in vitro airway epithelial tissue model to evaluate the respiratory toxicity of orthophthalaldehyde
Author: Diego Rua / FDA/CDRH
3D Models for the Alveolar Barrier
Author: Arno Gutleb / LIST
In vitro model for the prediction of respiratory sensitization
Author: Chary A., Serchi T., Cambier S., Moschini E., Contal S., Hennen J., Ezendam J., Blömeke B., Gutleb A.C./ LIST
Sub-ohm vaping is cytotoxic, alters gene expression and levels of reactive oxygen-nitrogen species in human lung epithelial cells
Authors: Alexandra Noël, Ekhtear Hossain, Rakeysha Pinkston / Louisiana State University
Molecular signature of asthma-enhanced sensitivity to aerosols of pristine and carboxylated CuO nanoparticles, identified in 3D cell models
Authors: Ingeborg Kooter, Marit Ilves, Mariska Gröllers-Mulderij, Evert Duistermaat, Peter C. Tromp, Frieke Kuper, Pia Kinaret, Kai Savolainen, Dario Greco, Piia Karisola, Joseph Ndika, Harri Alenius / TNO
Characterization of an Air-Liquid-Interface (ALI) In Vitro Exposure System (VITROCELL® VC1/7 and VITROCELL® 24/48)
Using a Prototype E-vapor Product Authors: Jingjie Zhang1, Michael Oldham1, Utkarsh Doshi1, I. Gene Gillman2, Russell L. Wolz2, Pavel Kosachevsky2, Bonnie Coffa1, Willie J. McKinney1, K. Monica Lee1 1Altria / 2Enthalpy
Comparison of Deposition Efficiency and Uniformity of Monodisperse Solid Particle Deposition in Two Air Liquid Interface (VITROCELL® 24/48 and AMES 48) In Vitro Exposure Systems with Computational Fluid Dynamic (CFD) Predictions
Authors: Michael Oldham1, Jingjie Zhang1, I. Gene Gillman2, Pavel Kosachevsky2, F. Lucci3, A. K. Kuczaj3, N. D. Castro1, A. A. Rostami1, Y. B. Pithawalla1, Julia Hoeng3, Willie J. McKinney1, K. Monica Lee1 1Altria / 2Enthalpy / 3PMI
The next VITROCELL® User Group Meeting will be held In Europe on 13 May 2020 in the Europa-Park Rust, Germany. Details will be announced on our website.