Advanced in vitro exposure systems.

11. Mar. 2018

New Products at VITROCELL® User Group Meeting 2018

10 March 2018, Grand Hyatt San Antonio, Texas, USA

Following the VITROCELL® User Group Meeting 2017 in Baltimore, international scientists from Canada, Europe, Japan and USA reconvened in March 2018.

The informal event organized into short presentations and posters was followed by open discussions. It was an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange your experience in working with the equipment and to meet other fellow researchers. The meeting took place prior to the international Society of Toxicology 57th Annual Meeting and ToxExpo, March 11 – 15, 2018, in San Antonio, USA - one of the largest international conferences related to toxicology.

Focus of the event was to share VITROCELL® activities since the last meeting, to exchange latest research results, to give an update on VITROCELL’s participation in major research programs as well as the presentation of new products for 2018.

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28. Oct. 2018

Big tobacco embraces in vitro toxicology

Manufacturers invest in nonanimal tests to evaluate health risks of e-cigarettes and other next-generation tobacco products

c&en, Volume 96, Issue 43

Britt E. Erickson

The complexity of next-generation tobacco products has increased by a number of factors since FDA was given responsibility to regulate tobacco. Testing e-liquids with animals is not practical, economically and not that accurate. The Vitrocell system generates airborne materials from test products, such as smoke from reference cigarettes and vapor from e-cigarettes, in a manner that simulates how a person would puff. This artcile shows, how IIVS scientists use human donor tissues, obtained from organs, to create cell cultures and in vitro test systems.


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23. Oct. 2018

Society of Toxicology's 58th Annual Meeting and ToxExpo

March 10–14, 2019. Baltimore Convention Center - Baltimore, Maryland, USA. Booth #3850

The Society of Toxicology 58th Annual Meeting and ToxExpo promises stimulating lectures and presentations on scientific breakthroughs, important education and professional training opportunities, and time to connect with old friends and create new collaborations.

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Categories: Exhibitions

Tags: congress

10. Sep. 2018

20th International Congress on In Vitro Toxicology (ESTIV2018)

October 15–18, 2018. Germany, Berlin. Booth #26

The general theme of the Congress is “New approach methodologies for in vitro toxicology applications”. This slogan is fully reflected in the 8 thematic sessions to which you can submit abstracts for oral or poster presentation. Abstract authors will be invited to prepare an original research manuscript or review paper to be taken into consideration for the ESTIV2018 proceedings that will be published in the journal Toxicology In Vitro.

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Categories: Exhibitions

Tags: congress

10. Jul. 2018

9th International Conference on Nanotoxicology (NanoTox 2018)

September 18–21, 2018. Germany, Neuss. Booth #A1

More than ten years have passed since the first NanoTox conference – time to summarize the research of the last decade and look ahead on what’s to come.

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Categories: Exhibitions

Tags: congress

6. Jul. 2018

54th Congress of the European Societies of Toxicology (EUROTOX)

September 2–5, 2018. Brussels, Belgium. Booth #24

The theme for 2018 is “Toxicology Out of the Box”. It reflects the willingness and enthusiasm to offer a really innovative, forward-looking and imaginative scientific programme.

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Categories: Exhibitions

Tags: congress

30. Jun. 2018

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

DOI 10.1016/j.jaerosci.2018.06.015

 

Francesco Luccia, Nicolas D. Castrob, Ali A. Rostamib, Michael J. Oldhamb, Julia Hoenga, Yezdi B. Pithawallab, Arkadiusz K. Kuczajac

a Philip Morris International Research & Development, Philip Morris Products S.A. (part of Philip Morris International group of companies), Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
b Altria Client Services LLC, Center for Research and Technology, Richmond, VA 23219, USA
c Multiscale Modeling & Simulation, Dept. of Applied Mathematics, University of Twente, P.O.Box 217, 7500 AE Enschede, The Netherlands

This paper successfully presents the geometry and characteristic dimensions of the two exposure systems: Vitrocell 24/48 and Vitrocell AMES 48. A computational modeling of aerosol transport and deposition shows the deposition efficiency.


 

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15. Jun. 2018

ACE nano: pursuing analytical and characterisation excellence in nanomaterial risk assessment

Nanomaterials are man-made materials of a size thousands of times smaller than the width of a human hair. They have fascinated scientists and industry with their unique and unpredictable properties, which have given rise to an endless variety of new applications in every sector of technology and medicine. As a result, an ever-increasing number of nanomaterials are entering the market in everyday products spanning from healthcare and leisure to electronics, cosmetics and foodstuffs. However, the novelty in exploitable properties may be mirrored by new hazards and, in order to manage these, a well-founded and robust legislative framework that will ensure safe development of nano-enabled products is needed.

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Categories: Product News

Tags: nanoparticles

6. Jun. 2018

Distribution of polymer-coated gold nanoparticles in a 3D lung model and indication of apoptosis after repeated exposure

DOI: 10.2217/nnm-2017-0358

Savvina Chortarea1,2, Kleanthis Fytianos1,3,4, Laura Rodriguez-Lorenzo1, Alke Petri-Fink1,5 & Barbara Rothen-Rutishauser1
1BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
2Laboratory for Particles – Biology Interactions, Empa, Swiss Federal Laboratories for Materials, Science & Technology, St Gallen, Switzerland
3Department of Pulmonary Medicine, University of Bern, Bern, Switzerland
4Department of Clinical Research, University of Bern, Bern, Switzerland
5Department of Chemistry, University of Fribourg, Fribourg, Switzerland

The distribution and impact of aerosol-delivered functionalized AuNPs upon repeated administration were explored in a complex in vitro human lung epithelial tissue barrier model applying an air–liquid interface exposure approach. Nanoparticles were aerosolized using the Air-Liquid Interface system consisting of a nebulizer, an exposure and an incubation chamber connected to an air-flow system to provide optimum conditions for cell cultivation as well as a quartz crystal microbalance for online measurements of the NP dose deposited on the cells surface.

 

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1. Jun. 2018

Charakterisierung von Partikelemissionen aus dem Trennschleifprozess von kohlefaserverstärktem Beton (Carbonbeton)

Autoren:
Hillemann, L.; Stintz, M.; Streibel, T.; Zimmermann, R.; Öder, S.; Kasurinen, S.; di Bucchianico, S.; Kanashova, T.; Dittmar, G.; Konzack, D.; Große, S.; Rudolph, A.; Berger, M.; Krebs, T.; Saraji-Bozorgzad, M. R.; Walte, A.

Die Wirkung von Emissionen aus dem Trennen von Carbonbeton werden in einer Kombination aus Trennstaubgenerator, Verdünnungssystem und Expositionssystem an Zellkulturen (A549 und THP-1) gegenüber den entstehenden Stäuben bestimmt (Zytotoxizität).

 

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