The VITROCELL® Automated Exposure Station has been specifically designed and engineered to facilitate the research of the direct exposure of human cell cultures to airborne substances such as gases, complex mixtures, nanoparticles and fibers at the air/liquid interface. The system authentically simulates the conditions of human physiological exposure.
It offers a capacity of up to 21-cell culture compartments for exposure and 3 compartments for clean air control.
All key functions for successful exposure such as, aerosol flow rates, humidity, temperature and leak test are edited by touch-screen prior to the experiment. The respective data is shown on live graphs and stored for further analysis. The cells are exposed at the air/liquid interface on 6/12/24-well sized cell culture inserts. The isokinetic sampling system enables a uniform delivery of the test substance to the cells. High voltage charging increases deposition efficiency.
Post-exposure the cells are further processed to measure a wide range of endpoints, e.g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation. See also the VITROCELL® assay guide for further information.