September 2013
Authors
Joost Vos1, Yvonne Staal1, Jos van Triel1, Frédérique van Acker1, Astrid Reus1, Evert Duistermaat1, Wilfred Maas1, Mariska Gröllers-Mulderij2, Maaike Steenhof2, Rob Stierum2, Linette Pellis2, Eugene van Someren2, Eric Schoen2, Frieke Kuper2 Ingeborg Kooter2
1 TNO Triskelion B.V., P.O.BOX 844, 3700 AV Zeist, The Netherlands
2 TNO, P.O.BOX 360, 3700 AJ Zeist, The Netherlands
For further information: joost.vos@tno.triskelion.nl
The poster shows that the respiratory epithelium model allows the assessment of bioavailability and safety of pharmaceutical and chemical compounds in the airways and lungs. The radio-labelled aerolosized nano particles are exposed to the cells on the air-liquid interface with the endpoints of TEER, HO-1, LDH, Comet-Assay and Illumina gene array expression analysis.
