Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida.
Authors; M. J. Scian1, L. E. McFadden1, C.M. Sovick1, C. D. Damron1, E. D. Sill1, I. Crooks2, D. Breheny2, E. Bishop2, R. Weil1, and W. McKinney1
1McKinney Specialty Labs, Richmond, VA, USA;
2B.A.T. (Investments) Limited, Southampton, United Kingdom, SO15 8TL
- Aerosol delivery to the exposure wells using this exposure setup can be tailored based on dilution flow, removal of aerosol, and/or the number of puffs taken to meet or exceed OECD assay guidelines.
- Gravimetric measurements are a good approximation for the aerosol mass delivered but do not appear to be sufficiently accurate in comparison to nicotine measurements.
- Aerosol residue was present in the walls of both the 35 mm plates and the 6-well Transwells in some runs (not shown). This may partially help explain some of the observed discrepancy between the gravimetric nicotine estimates and nicotine measurements.
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