Characterisation of an in vitro air-liquid interface (ALI) Inhalation exposure system.

June 3, 2025

Poster: AIT – Association of Inhalation Toxicologists Conference, June 3-5 2025, Milton Keynes, United Kingdom

Matthew Sheavyn, Victoria Pack
Human and Biological Advantage, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

Introduction
In vitro inhalation exposure systems have emerged as popular potential solutions for studying toxicological effects of aerosols. These systems are becoming increasingly complex in their function. The VITROCELL® Cloud Alpha MOVE features a quartz Crystal microbalance (QCM) for dosimetry, and a sequential dosing mode which uncovers wells during the experiment to study dose-Response relationships. It is important that characterisation and validation of new systems is performed Prior to study design and first use.

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