https://doi.org/10.3389/ebm.2025.10606
Cheng Wang1, Leah E. Latham1, Shuliang Liu1, John Talpos1, Tucker A. Patterson2, Joseph P. Hanig3, Fang Liu1;
1 Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States
2 Office of Center Director, National Center for Toxicological Research/Food and Drug Administration (FDA), Jefferson, AR, United States
3 Office of Pharmaceutical Quality, Center for Drug Evaluation and Research/FDA, Silver Spring, MD, United States
Xenon + propofol (Molecular Neurobiology, 2020): In human neural stem cell–derived neurons, prolonged propofol (50 µM, 16 h) reduced the neuronal marker PSA‑NCAM and caused morphologic damage, while co‑exposure to xenon (33%) prevented PSA‑NCAM loss and promoted its re‑expression after enzymatic removal; xenon alone was not harmful. The findings suggest xenon may mitigate anesthetic‑induced neurotoxicity by supporting PSA‑NCAM–related neuronal plasticity.
