Poster, SOT 64th Annual Meeting and ToxExpo, March 16–20, 2025, Orlando, Florida.
Breandon Taylor1, Alexandra Noël2, Daniel Conklin1, and Sanjay Srivastava1
1University of Louisville Superfund Research Center and Envirome Institute, Louisville, KY, U.S.A
2Louisiana State University Superfund Research Center, Baton Rouge, LA, U.S.A
Air-liquid interface (ALI) may provide a more physiologically relevant approach for modelling human inhalation exposures in vitro. 1,3-BD exposure may promote carcinogenesis in human bronchial epithelial cells (BEAS-2B) by activating GREM1 to potentiate epithelial-mesenchymal transition (EMT) through stimulation of the PI3K/AKT signaling pathway. Overexpression of SERPINB2 may serve as an initial protective mechanism to reduce cell migration & EMT.
