A lab scale measurement technique for the air-liquid interface exposure of human lung cell cultures towards particulate emissions from combustion processes

¹S. Mülhopt, ³M. Berger, ¹C. Schlager, ²M. Dilger, ²S. Diabaté, ³T. Krebs, ^4,5Ralf Zimmermann, ⁴Jeroen Buters, ⁴Sebastian Oeder, ²C. Weiss, ¹H.-R. Paur

¹Institute for Technical Chemistry
²Institute of Toxicology and Genetics
³Vitrocell Systems GmbH, Germany
⁴Helmholtz CentreMunich, Germany
⁵University of Rostock, Germany
 

The Karlsruhe Exposure System is a lab scale measurement system for the air-liquid interface exposure of human lung cell cultures towards air borne nanoparticles under well defined conditions.

Background
Numerical simulations by Kiesewetter et al. show: also in 15 years the European limits for PM10 immissions will not be complied.
figure: predicted PM10 concentrations in 2030
→New assessment methods for biological responses of immissions are required.

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