VITROCELL® 12/3 and 12/4 CF Stainless Steel

Stainless Steel modules for 12-well sized inserts

The VITROCELL® 12 CF module system has been specifically designed and engineered to facilitate the research of human cell cultures direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure.

Base Module

This modules’ casing is made of electropolished stainless steel. It is designed with three or four compartments for 12-well cell culture inserts and is fully autoclavable at 121° C (250° F) for 20 min. Through the employment of a special adapter set, this module can also be flexibly combined for use with 24-well cell culture inserts. A constant unit temperature is guaranteed using a regulated flow of temperature-controlled water through the module.

The medium can be supplied individually to each well compartment. Flexible medium exchange can be static, intermittent or continuous basis, this flexibility is afforded by use of a precision medium pump. This module is renowned in scientific circles for its reliability and durability.

More about 12/3 and 12/4 CF Stainless Steel

Aerosol exposure top

The aerosol inlet-stream flows through specially shaped inlets.

3 types of aerosol-inlet materials are available:

  • Stainless Steel
  • Stainless Steel with unique VITROGLIDE surface treatment

The stainless steel / VITROGLIDE inlets are specially designed for aerosols containing nano-range particles. VITROCELL® calibration valves are connected to a vacuum pump to control flow rates effectively. The aerosol exposure top features an in/outlet for heating the water circuit, ensuring corresponding temperatures with the base module. It is made of high-quality anodized aluminum.

Controlled inlet flow

VITROCELL® exposure systems have been specifically designed and engineered to give researchers the possibility of directly exposing mammalian cells or tissue at the air/liquid interface. Thus, all cell types cultivated on microporous membranes can be used. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.

Option for microbalance sensor

The QCM sensor can be integrated in the exposure module. It is capable of measuring the deposited mass in nanogram/cm2 per second. Results are reported online by the VITROCELL® Monitor software. Data is presented in graphs and stored in MS Excel®.


Universal module with optional adaptor sets for:

  • 12-well sized inserts
  • 24-well sized inserts

All commercial brands are supported.


  • Suitable for COSTAR®, FALCON® and ThinCert® 6-well sized cell culture inserts
  • Adaptors for 12 and 24-well sized inserts
  • Individual media inlets and outlets for each cell culture insert compartment
  • Special inlet geometry of the aerosol exposure top for optimal particle deposition
  • Inlets made of stainless steel with a unique VITROGLIDE surface treatment
  • Base module made of electropolished stainless steel
  • Base module and aerosol exposure top with integrated water heating circuit
  • Control window for monitoring culture medium levels
  • Autoclavability of all components
  • Suitable for VITROCELL® Quartz Crystal Microbalance
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VITROCELL® 12/3 and 12/4 CF Stainless Steel

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