Testing Nanomaterials In Complex 3D In Vitro Lung Models

September 11, 2024

Poster Eurotox 08.-11.September 2024, Copenhagen, Denmark

Emma Arnesdotter1, Pamina Weber1, Charlotte Stoffels1, Sebastian Klein1, Ionel Fizeşan2, Sebastien Cambier1, Elisa Moschini1,3, Tommaso Serchi1, Arno C. Gutleb1
1Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 41 Rue du Brill, L-4422 Belvaux.
2Department of Toxicology, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
3Institute of Biological Chemistry, Biophysics and Bioengineering, EPS, Heriot-Watt University, Edinburgh.

Objectives
Exposure of 3D models to NMs can be performed withmultiple exposure strategies, all with advantages and disadvantages that should be considered to ensure the physiological relevance of the Approach while having a high enough throughput. Here, we comment on exposure Systems based on extensive experience of in vitro testing of NMs in a 3D alveolar model.

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