August 30 - September 3, 2009
Smirnova, L.1, Liebsch, M.1, Tharmann, J.1, Pirow, R.1, Luch, A.1, Bauer, M.2, Graebsch, C.2, Linsel, G.3, Siemers, R.3, Berger-Preiß, E.4, Kock, H.4, Oertel, A.4, Riiter, D.4, Knebel, J.4
1 Federal Institute for Risk Assessment (BfR), Unit 37, Centre for Alternative Methods to Animal Experiments, ZEBET, Berlin, Germany
2 Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany
3 Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany
4 Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany
The aim of this study is to determine the in vitro vs. in vivo dose-response relationships. A549 cell were grwon in the air-liquid interface and exposed to NO2, SO2, formaldehyde and ozone. The results are measured in cytotoxicity (viability) and genotoxicity (COMET assay). The project has proved satisfying. transferability of the test method.