Advanced in vitro exposure systems.

30. Mar. 2008

SOT Meeting Seattle

VITROCELL® SYSTEMS reports increasing interest in aerosol generators and biological test systems for nano particles at the 2008 SOT Annual Meeting

VITROCELL presents the direct exposure technology for the in vitro analysis of airborne substances such as gases, nano particles and complex mixtures.

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Categories: Product News

Tags: inhalation exposure

10. Mar. 2008

The Response of a Co-culture Lung Model to Fine and Ultrafine Particles of Incinerator Fly Ash at the Air-liquid Interface

ATLA

ATLA, Issue 36, pp. 285-298, 2008

Authors
Silvia Diabaté, Sonja Mülhopt, Hanns-Rudolf Paur and Harald F. Krug

Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein - Leopoldshafen, Germany

 

BEAS-2B cells were exposed to an aerosol, generated from fly ash. The cells were co-cultured with differentiated THP-1 macrophages growing on Transwell inserts. Analyses of cell viability and IL-8 release were performed.

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10. Mar. 2008

Exposure of a multi-cellular in vitro model of human airway tissue to the whole cigarette smoke

Respiratory and Critical Care Medicine

Vol 177 (Abstracts Issue): pA728 (2008)

Authors
Walsh, P.T., Chalupowicz, D.G., Frankowski, R., Barnette, M.

Discovery Biology, Respiratory CEDD, GlaxoSmithKline, Upper Merion, PA19406, USA

 

HBE cells were exposed in a single and repeated whole smoke situation. The cells were analysed for changes in gene expression (RT-PCR) and cell viability was confirmed using the MTT assay and release of IL-1, IL-6 and IL-8.

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10. Mar. 2008

Cellular responses of primary human bronchial epithelial cells to whole cigarette smoke exposure

Respiratory and Critical Care Medicine

Vol 177 (Abstracts Issue): pA199 (2008)

Authors
Chalupowicz, D.G., Frankowski, R., Sanchez, Y., Kou, J., Barnette, M., and Walsh, P.T.

GlaxoSmithKline


Primary human bronchial epithelial cells were exposed in a single and repeated whole smoke situation. The cells were analysed for changes in gene expression (RT-PCR) and cell viability was confirmed using the MTT assay and release of IL-1, IL-6 and IL-8.

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31. Oct. 2007

In Vitro Testing of Inhalable Fly Ash at the Air Liquid Interface

Advanced Environmental Monitoring

October 2007, pp 402-414

Authors
Sonja Mülhopt, Hanns-Rudolf Paur, Silvia Diabaté and Harald F. Krug

Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein - Leopoldshafen, Germany

 

Exposure experiments with the fine and ultrafine fraction of fly ash on human lung cells in the air-liquid interface have shown an increased release of IL-8. 

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8. Oct. 2007

EUROTOX Congress

VITROCELL® SYSTEMS presents new equipment developments for in vitro inhalation toxicology at the EUROTOX 2007 (44th Congress of the European Societies of Toxicology) in Amsterdam, the Netherlands, October 7-10, 2007

Broad product program of equipment for the in vitro analysis of airborne substances such as gases, nano particles and complex mixtures was presented.

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Categories: Product News

Tags: inhalation exposure

7. Oct. 2007

Toxicological investigation of nanoparticles - effects on human cells

EUROTOX. Amsterdam, Netherlands.

October 7-10, 2007

Authors
Letizia Farmer, Alexander Graff, Sandra Szameit, Eva Valic, Helga Tuschl

Austrian Research Centers GmbH - ARC, Life Sciences, Toxicology, A-2444 Seibersdorf, Austria

 

Differentiated macrophages were seeded on human lung epithelial cells for co-culturing. As endpoints for particle exposure cell viability (WST-1 assay), oxidative stress (DHRAssay) and pro-inflammatory cytokines (BDTM CBA-Assay) were evaluated.

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8. Sep. 2007

News Release

VITROCELL® SYSTEMS reports successful participation in the 6th World Congress on Alternatives and Animal Use in the Life Sciences 21-25 August, 2007 in Tokyo.

Approximately 1.000 scientists from all over the world met in Tokyo to exchange their views on the latest developments on alternative methods to animal tests in life sciences.

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Categories: Product News

Tags: inhalation exposure

23. Jul. 2007

A modified Ames assay reveals the mutagenicity of native cigarette mainstream smoke and its gas vapour phase

ELSEVIER

Experimental and Toxicologic Pathology 58 (2007) 383-392

Authors
Michaela Aufderheide, Helga Gressmann

Department of In-Vitro Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany

 

Establishment of a new experimental approach for direct exposure of bacteria with actual generated smoke aerosol. This allowed us to investigate the mutagenic activity of native mainstream smoke on Salmonella Typhimurium strains. The new procedure of exposing bacteria directly to gases and complex mixtures offers new possibilities in the field of inhalation genotoxicology for the evaluation of genotoxicity in the Ames assay.

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23. Mar. 2007

Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface

Experimental Lung Research

33:1, 27 - 51, 2007

Authors
JeanClare Seagrave, Sandy Dunaway, Jacob D. McDonald, and Joe L. Mauderly
Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA

Patrick Hayden
MatTek Corp, Ashland, Massachusetts, USA

Christine Stidley
Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA

 

The study evaluated responses of human primary airway epithelial cells to diesel exhaust. This model may be useful for mechanistic and comparative toxicology studies.

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