Advanced in vitro exposure systems.

1. Jun. 2016

52nd Congress of the European Societies of Toxicology (EUROTOX)

Sept 04-07, 2016. Seville, Spain. Booth #54

The EUROTOX 2016 Scientific Programme Committee has prepared an exciting scientific programme, highlighting the latest research results and trends in the field of toxicology.

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1. Jun. 2016

The 30th Annual Conference of the Chinese Chemical Society

July 01-04, 2016. Dalian City, LiaoNing, China. Booth #54

30th Annual Conference for Chemical research held by the Chinese Chemical Society. With a total of 46 sessions, this event offers a great opportunity for discussion and exchange of knowledge.

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30. Apr. 2016

Assessing the mutagenic activities of smoke from different cigarettes in direct exposure experiments using the modified Ames Salmonella assay

Shinkichi Ishikawa, Yuki Kanemaru, Hidenori Nara, Kazuo Erami, Yasufumi Nagata

Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., 6-2 Umegaoka, Aoba-ku, Yokohama, Kanagawa 227-8512, Japan


This article shows the successful exposition exposure of cigarette smoke on two different Ames bacteria strains by using the Vitrocell exposure system including the VC10 smoking robot. Conventional 1 mg tar commercial cigarettes (CC1), 1R5F reference cigarettes (University of Kentucky,Lexington, KY, USA), and 3R4F reference cigarettes (University of Kentucky) were compared with a prototype heated cigarette (HC).

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25. Apr. 2016

International Nanotoxicology Congress

June 1 – 4, 2016. Boston, Massachusetts, USA.

The 2016 International Nanotoxicology Congress will take place in Boston, Massachusetts, USA, on June 1 – 4, 2016. This conference is the 8th in a continuing series of international meetings that are broadly focused on nanotoxicology, one that began in Boston in 2006. Thus, it is fitting that we return to this beautiful and historic city for our 10th anniversary meeting.

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25. Apr. 2016

8th Annual Quasi Vivo® User Group Meeting

May 30 - June 1, 2016. Barcelona, Spain. Hotel SB Plaza Europa.

This international meeting exploring Advances in Cell and Tissue Culture is hosted by Kirkstall Ltd. The ACTC conference aims to create an interdisciplinary forum in which professionals and research students working in cell culture can exchange knowledge, promote their activities and set up new collaborative projects.

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4. Apr. 2016

Cutting-edge in vitro Exposure Technologies for Conventional and E-cigarettes

IIVS Workshop. April 4-6, 2016. Washington

GAITHERSBURG, MD – April 12, 2016 – The Institute for In Vitro Sciences (IIVS) brought together stakeholders from industry, government and academia to discuss considerations for exposure and dosimetry for non-animal testing during its 2.5-day workshop, “In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products”, held April 4-6, 2016 in Bethesda, MD. Uniquely focused on in vitro testing, the workshop is the only known event of its kind. VITROCELL Systems had the opportunity to present Cutting-edge in vitro Exposure Technologies for Conventional and E-cigarettes.

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20. Mar. 2016

VITROCELL® User Group Meeting 2016

11 March 2016, Hilton New Orleans Riverside, USA prior to the Society of Toxicology 55th Annual Meeting and ToxExpo

After a successful User Group Meeting 2015 in the EUROPA-PARK in Germany, International scientists from Europe, Japan and USA followed the invitation of VITROCELL® Systems to the 2016 User Group Meeting.

It offered an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange experiences in working with VITROCELL® devices and to meet fellow researchers. The meeting took place prior to the international Society of Toxicology 55th Annual Meeting and ToxExpo – one of the largest international conferences related to toxicology.

The focus of the event was to present new routes dosimetry, to give an update on VITROCELL’s participation in major European research programs related to nanoparticles as well as the presentation of new products for 2016.

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15. Mar. 2016

A Proposed In Vitro Method to Assess Effects of Inhaled Particles on Lung Surfactant Function

DOI: 10.1165/rcmb.2015-0294MA

Jorid B. Sørli1, Emilie Da Silva1, Per Bäckman2, Marcus Levin1, Birthe L. Thomsen1, Ismo K. Koponen1, and Søren T. Larsen1
1The National Research Centre for the Working Environment, Copenhagen, Denmark
2AstraZeneca, Mölndal, Sweden

This study has demonstrated that the modified CDS, a novel method that mimics the conditions for the lung surfactant, is a useful bioassay to assess the acute effects of dry powder aerosols on the lung. The in vitro method, based on the constrained drop surfactometer, different Turbuhaler as well as empty Turbuhaler filled with albumin or lactose were tested. A quartz crystal microbalance was fitted in the chamber to estimate the dose of the deposited particles.

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14. Mar. 2016

Cellular Effects in an In Vitro Human 3D Cellular Airway Model and A549/BEAS-2B In Vitro Cell Cultures Following Air Exposure to Cerium Oxide Particles at an Air–Liquid Interface

DOI: 10.1089/aivt.2015.0030

Ingeborg M. Kooter,1 Mariska Gröllers-Mulderij,1 Maaike Steenhof,1 Evert Duistermaat,2 Frederique A.A. van Acker,2 Yvonne C.M. Staal,2 Peter C. Tromp,1 Eric Schoen,1 C. Frieke Kuper,1 and Eugene van Someren1

1The Netherlands Organisation for Applied Scientific Research, TNO, Utrecht, The Netherlands.
2TNO Triskelion BV, Zeist, The Netherlands.

BEAS-2B, A549, and MucilAir cells were exposed to CeO2 particles and are cultured at air–liquid interface. LDH, cytokine analysis, gene expression analyses, HO-1 analyses and Comet assay were used for evaluation. Cell responses in the MucilAir model exposed via air to CeO2 were minimal compared to those of the cell lines.

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9. Mar. 2016

Toxicity testing of combustion aerosols at the air-liquid interface with a self-contained and easy-to-use exposure system


Sonja Mülhopt a, i, Marco Dilger a, b, i, Silvia Diabaté b, i, Christoph Schlager a, i, Tobias Krebs c, i, Ralf Zimmermann d, h, i, Jeroen Buters e, i, Sebastian Oeder e, g, i, Thomas Wäscher f, Carsten Weiss b, i, Hanns-Rudolf Paur a, i

a Karlsruhe Institute of Technology, Institute for Technical Chemistry, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
b Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
c Vitrocell Systems GmbH, Fabrik Sonntag 3, 79183 Waldkirch, Germany
d University of Rostock, Institute of Chemistry, Dr.-Lorenz-Weg 1, 18051 Rostock, Germany
e Center of Allergy & Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Biedersteiner Str. 29, 80802 München, Germany
f Ingenieurbüro für Energie- und Verfahrenstechnik, Von-Dalheim-Str. 2, 69231 Rauenberg, Germany
g Kühne Foundation, Christine Kühne Center for Allergy Research and Education (CK- CARE), München, Germany
h Cooperation Group “Comprehensive Molecular Analytics” – CMA, Helmholtz Zentrum München, 85764 Oberschleißheim/ Germany
i HICE – Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health – Aerosols and Health



• We present a fully automated Air-Liquid-Interface Exposure System.
• System characterisation shows a high reproducibility.
• Wood combustion aerosol causes cytotoxicity in human lung epithelial cells.
• Gene regulation caused by ship diesel emissions in human lung epithelial cells.

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