Sandro Steiner, Shoaib Majeed, Arkadiusz Kuczaj, Julia Hoeng, Stefan Frentzel
Philip Morris International R&D, Philip Morris Products S.A. (part of Philip Morris International group of companies)

Establishment of a setup for sampling and analyzing complex aerosols on-line during exposures with the Vitrocell 24/48 aerosol exposure system.
The poster was presented at Eurotox 2017, http://www.eurotox2017.com

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DOI:10.1038/s41598-017-11038-x
Juliette Sailland¹, Astrid Grosche^1,3, Nathalie Baumlin¹, John S. Dennis¹, Andreas Schmid¹, Stefanie Krick^1,2 & Matthias Salathe^1
1 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
² Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
³ Department of Radiation Oncology, University of Florida, Gainesville, FL, 32610, USA.

The aim of the study is to examine the effects of cigarette smoke on voltage dependent K+ channels, cystic fibrosis transmembrane conductance regulator activity and airway surface liquid volume on primary human bronchial epithelial cells from non-smokers and smokers, cultured at the air-liquid interface to full differentiation.

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Anita R. Iskandar, Yannick Martinez, Carole Mathis, Patrice Leroy, Florian Martin, Alan Sewer, Laura Ortega Torres, Shoaib Majeed, Keyur Trivedi, Stefan Frentzel, Emmanuel Guedj, Celine Merg, Ashraf Elamin, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng

Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland (part of Philip Morris International group of companies)

The aim of the study is the characterization of the 3R4F smoke and CHTP1.2 aerosol in the Vitrocell 24/48® exposure system including the measurements of nicotine in the diluted 3R4F smoke and THS2.2 aerosol. Cytotoxicity was assessed, concentrations of pro-inflammatory mediators were measured, mRNA microarrays and the histological analysis were done.

The poster was presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, Washington, USA.

http://wc10seattle.org/2017/home.aspx

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We are pleased to invite you to the 7^th International Conference on Nanoscience and Technology, China 2017 (ChinaNANO 2017) which will be held between August 29-31, 2017 in Beijing, China.

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Schmid O^1,2, Jud C³, Umehara Y³, Mueller D⁴, Bucholski A⁴, Gruber F⁴, Denk O⁴, Egle R⁴, Petri-Fink A³, Rothen-Rutishauser B³.

¹ Comprehensive Pneumology Center (CPC), German Center for Lung Research (DZL) , Munich, Germany .
² Institute of Lung Biology and Disease, Helmholtz Zentrum München-German Research Center for Environmental Health , Neuherberg, Germany .
³ BioNanomaterials, Adolphe Merkle Institute, University of Fribourg , Fribourg, Switzerland .
⁴ PARI Pharma GmbH, Starnberg, Germany .

The lung epithelial barrier was studied in vitro. Human lung epithelial cells (alveolar A549 and bronchial 16HBE14o- epithelial cells) were exposed to an aerosolized immunosuppressive drug encapsulated in liposomes at the air-liquid interface (ALI) using a dose-controlled air-liquid interface cell exposure (ALICE) system.

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