Sonja Mülhopt1, Christoph Schlager2, Markus Berger2, Sivakumar Murugadoss3, Peter H. Hoet3, Tobias Krebs2, Hanns-Rudolf paur1 & Dieter Stapf1
1Karlsruhe Institute of Technology (KIT), Institute for Technical Chemistry, Eggenstein-Leopoldshafen, 76344, Germany.
2Vitrocell Systems GmbH, Waldkirch, 79183, Germany.
3KU Leuven, Environment and Health, Leuven, 3000, Belgium.
The surface dose and the spatial distribution on the membrane delivers important data for measuring dose-response relationships in toxicity studies. Image evaluation of transmission electron microscopy (TEM) samples is a highly sensitive method for determination of deposition. This paper reports the development and characterization of a novel holder for film coated TEM copper grids, which allows for sampling under identical geometric and ambient conditions as in a cell culture chamber.