Advanced in vitro exposure systems.

In vitro advances in whole aerosol approaches for e-cigarette testing

24. Feb. 2020

IIVS Workshop 3, Feb 24-26th 2020

Autor

David Thorne, British American Tobacco

 

Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro data for product regulation.

 

Conclusions
• In vitro techniques have to evolve alongside new emerging products
• Can not rely on traditional cigarette smoke testing approaches. These new categories are chemically and physically different and should be treated as such
• Future e-cigarette (&THP) testing should consider the following aspects to ensure appropriate conclusions/interpretation of data:• Aerosol delivery (Dose) • Applied dosimetry approaches to make the data more meaningful (bridging of data) • Contextualisation of data through human consumption and dose extrapolation
• We have demonstrated the evolution of techniques, which has allowed us to bridge between platforms, simplify exposure setup, experimental design and demonstrate e-cigarette technology evolution 

 

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