Human cell-based in vitro systems to assess respiratory toxicity: A case study using silanes

March 19, 2023

SOT 62nd Annual Meeting and ToxExpo, March 19-23 2023, Nashville, Tennessee, USA

Monita Sharma1, Andreas O. Stucki1, Sandra Verstraelen2, An Jacobs2, David Poelmans2, Sylvie Remy2, Frederick Maes2, Jo Van Laer2, Karen Hollanders2, Lieve Geerts2, Stefan Voorspoels2, Evelien Frijns2, Amy J. Clippinger1
1PETA Science Consortium International e.V., Stuttgart, germany
2VITO, Flemish Institute for Technological Research, Mol, Belgium

Silanes are widely used as reducing and coupling agents with applications in surface modifications. Because of their reactivity and rapid hydrolyzation, occupational exposure to silanes is possible in the production line. In this study, called the INSPiRE Initiative (IN vitro System to Predict REspiratory toxicity),a human bronchial epithelial cell line(BEAS-2B) and a reconstructed human tissue model (MucilAir™) were exposed to triethoxysilane (TES) and trimethoxysilane (TMS) as vapors, to predict the ability of these chemicals to cause portal-of-entry effects on the human respiratory tract.

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