Exposure of human lung cells to inhalable substances

March 30, 2003

Inhalation Toxicology, 15:67-84, 2003

Detlef Ritter, Jan W. Knebel, Michaela Aufderheide


The experimental setup included online monitoring of the gas phase and particulate phase. A cell exposure of different smoke and synthetic air periods was sufficient to cause different effects as measured by intracellular glutathione content. The fact that the system could differentiate between different types of cigarette smoke demonstrated its high sensitivity and specificity. 

A novel test strategy involving clean air exposure periods using whole dilution cigarette mainstream smoke.


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