Evaluation of a human in vitro 3D respiratory epithelium model in bioavailability and safety assessment of pharmaceutical and chemical compounds

September 30, 2013

September 2013

Joost Vos1, Yvonne Staal1, Jos van Triel1, Frédérique van Acker1, Astrid Reus1, Evert Duistermaat1, Wilfred Maas1, Mariska Gröllers-Mulderij2, Maaike Steenhof2, Rob Stierum2, Linette Pellis2, Eugene van Someren2, Eric Schoen2, Frieke Kuper2 Ingeborg Kooter2

1 TNO Triskelion B.V., P.O.BOX 844, 3700 AV Zeist, The Netherlands
2 TNO, P.O.BOX 360, 3700 AJ Zeist, The Netherlands
For further information: joost.vos@tno.triskelion.nl


The poster shows that the respiratory epithelium model allows the assessment of bioavailability and safety of pharmaceutical and chemical compounds in the airways and lungs. The radio-labelled aerolosized nano particles are exposed to the cells on the air-liquid interface with the endpoints of TEER, HO-1, LDH, Comet-Assay and Illumina gene array expression analysis.

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