An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke

February 25, 2003

Exp Toxic Pathol 2003; 55: 51-57

Michaela Aufderheide, Jan W. Knebel, and Detlef Ritter


The study presented a system that enables the direct exposure of human lung cells to native, unmodified cigarette mainstream smoke and also the demonstration of reproducible particle deposition depending on smoke concentration. Furthermore, it was shown that the exposed cells maintained their viability. The results were shown in measuring the cellular viability, ATP and glutathione content. 

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