August 25th–30th in Tampere, Finland. An excellent opportunity to discuss ALI exposures.
Session title: “Toxicity of Aerosols: Exploring Air-Liquid Interface Exposure.”
WG 4: Aerosols and Health
Alexandre ALBINET (INERIS, France)
Mathilde DELAVAL (Helmholtz Zentrum München, Germany)
Maurizio GUALTIERI (Università degli Studi di Milano-Bicocca, Italy)
The health implications of aerosols are widely acknowledged. The toxicological processes driving the effects associated with aerosols have been studied using in vivo and/or in vitro models. The latter involve usually exposing cells cultured under submerged conditions to particulate matter. However, this method has significant limitations and fails to authentically replicate aerosol properties, the physiology of the lung tissues and ultimately the effects of aerosol exposure. Exposure at the air-liquid interface (ALI) provides a more realistic simulation of real physiological conditions, offering a more accurate representation of aerosol exposure effects.
This session aims to provide a comprehensive platform for international experts from academia, government, and industry to share their research on various aspects of the application and utilization of the air-liquid interface (ALI) approaches to assess and explore the toxicity of aerosols. By consolidating various ALI studies into a singular session, we anticipate fostering enriched discussions, encouraging collaborative efforts, and advancing collective knowledge in this specialized field involving aerosols chemists, physicists, and toxicologists.
Contributions to the session are invited on a range of topics, encompassing but not limited to ALI exposure parameters and metrology, ALI exposure instrumentation, cell models, targeted endpoints, cell exposure dose evaluation, toxicity of both primary and secondary aerosols (gaseous and particulate phases), as well as laboratory, bench-scale (e.g., combustion sources) and ambient air experiments, considering both outdoor and indoor environments.
Additionally, we encourage submissions of comparison studies between ALI methods and conventional in vitro approaches, along with investigations exploring the correlation between aerosol physicochemical characteristics and biological effects. Finally, the presentation of new approach methodologies, also covering organ-on-a-chip applications, relevant to this field are highly encouraged.