A method for assessment of the genotoxicity of mainstream cigarette-smoke by use of the bacterial reverse-mutation assay and an aerosol-based exposure system

July 15, 2014

Volume 769, 15 July 2014, Pages 20–28, [epub ahead of print]

Joanne Kilforda, David Thorneb, Rebecca Paynea, Annette Dalrympleb, Julie Clementsa, Clive Meredithb, Debbie Dillonb

a Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK
b British American Tobacco, Group R&D, Southampton, Hampshire SO15 8TL, UK

Successfull modifikation of the Ames assay for the testing of a mainstream cigarette smoke aerosol that is generated with a VC 10® exposure system. The reproducebility of the response on a second VC 10® system is shown.

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