VITROCELL® 24/48 Exposure System

for 48 cell culture inserts (24-well size)

The VITROCELL® 24/48 module system has been ­specifi­cally designed and engineered to facilitate the research of human cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nano­particles and fibers. The system authentically simulates the conditions of human physiological exposure.

7 dilutions with 6 inserts each are used for for exposure to the substances and 6 inserts in the same system for clean air control. Each dilution represents a different dose concentration, so that a complete dose / response profile can be obtained in one experiment.

Climatic Chamber

The Climatic Chamber enables a condensation-free operation. It accomodates all required components of the VITROCELL® 24/48 System. The humidification station, pre-heating system for dilution air and flow ­controllers are mounted inside the chamber for constant ­temperature and increased humidity output.

Base module

8 rows @ 6 replicates

The base module with 48 wells (24-well-size) is made of electropolished stainless steel. An optional transparent control window facilitates the external monitoring of media levels and may be easily removed from the integrated heating base. Temperature can be programmed individually.

Insert size

The module has been designed for 24-well sized cell culture inserts.

Aerosol exposure top

48 inlets with indidual vacuum flow

Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top.

The aerosol exposure top guides the test atmosphere at an individually controlled flow rate to each cell culture membrane.

Controlled inlet flow

VITROCELL® exposure systems have been specifically designed and engineered to give researchers the possibility of directly exposing mammalian cells or tissue at the air/liquid interface. Thus, all cell types cultivated on microporous membranes can be used. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.

Integrated Dilution Systems

New support and quick-mounting mechanism of dilution systems and exposure top for easier handling.

Integrated Humidification Station

The Humidification Station inside the chamber allows for a stable delivery of humidified dilution air.

Integrated Flow Controllers

Flow controllers integrated in climatic chamber.

Controlled Heating System

Climatic Chamber can be heated to 37 °C to avoid condensation and enable stable humidity level.

24/48 PLUS Version

8 additional compartments for dosimetry

The 8 dosimetry positions can be equipped with either Quartz Crystal Microbalances, TEM Grid Holders or stainless Dosimetry Inserts for aerosol trapping in liquids.


  • Base module for 24-well sized inserts
  • 8-fold Dilution/Distribution System
  • 8 mass flow controllers for humidified air
  • Flow controllers mounted inside of chamber
  • 7 dilutions @ 6 replicates
  • 1 clean air control @ 6 replicates
  • Electronic heating system for base module
  • Climatic Chamber for condensation-free operation if using liquid aerosols
  • Housing with double-doors
  • Heating systems with two RH/T sensors for temperature monitoring
  • Integrated humidification system
  • Optional dosimetry compartments
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VITROCELL® 24/48 Exposure System

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