for 48 cell culture inserts (24-well size)
The VITROCELL® 24/48 module system has been specifically designed and engineered to facilitate the research of human cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure.
7 dilutions with 6 inserts each are used for for exposure to the substances and 6 inserts in the same system for clean air control. Each dilution represents a different dose concentration, so that a complete dose / response profile can be obtained in one experiment.
The Climatic Chamber enables a condensation-free operation. It accomodates all required components of the VITROCELL® 24/48 System. The humidification station, pre-heating system for dilution air and flow controllers are mounted inside the chamber for constant temperature and increased humidity output.
The base module with 48 wells (24-well-size) is made of electropolished stainless steel. An optional transparent control window facilitates the external monitoring of media levels and may be easily removed from the integrated heating base. Temperature can be programmed individually.
The module has been designed for 24-well sized cell culture inserts.
Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top.
The aerosol exposure top guides the test atmosphere at an individually controlled flow rate to each cell culture membrane.
VITROCELL® exposure systems have been specifically designed and engineered to give researchers the possibility of directly exposing mammalian cells or tissue at the air/liquid interface. Thus, all cell types cultivated on microporous membranes can be used. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
New support and quick-mounting mechanism of dilution systems and exposure top for easier handling.
The Humidification Station inside the chamber allows for a stable delivery of humidified dilution air.
Flow controllers integrated in climatic chamber.
Climatic Chamber can be heated to 37 °C to avoid condensation and enable stable humidity level.
The 8 dosimetry positions can be equipped with either Quartz Crystal Microbalances, TEM Grid Holders or stainless Dosimetry Inserts for aerosol trapping in liquids.