Silica nanoparticles are less toxic to human lung cells when deposited at the air-liquid interface compared to conventional submerged exposure

2014, 5, 1590–1602 (doi:10.3762/bjnano.5.171)

Authors
Alicja Panas¹, Andreas Comouth², Harald Saathoff², Thomas Leisner², Marco Al-Rawi¹, Michael Simon³, Gunnar Seemann³, Olaf Dössel³, Sonja Mülhopt⁴, Hanns-Rudolf Paur⁴, Susanne Fritsch-Decker¹, Carsten Weiss¹and Silvia Diabaté¹

¹ Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Campus North, Hermann- von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
² Institute for Meteorology and Climate Research, Karlsruhe Institute of Technology, Campus North, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
³ Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Campus South, Kaiserstraße 12, 76128 Karlsruhe, Germany
⁴ Institute for Technical Chemistry, Karlsruhe Institute of Technology, Campus North, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Exposition of humidified nanoparticles on A549 lung epithelia cells using the air-liquid interface. The experiments shows less cytotoxic and inflammatory responses of the cells to silica nanoparticles.

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