Advanced in vitro exposure systems.

NanoCELL - Comprehensive characterization and human toxicological assessment of cellulose nanocrystals along their life cycle for reliable risk assessment

28. Sep. 2020

Yvonne Kohl1, Roland Drexel2, Christine Herrmann3, Stephan Dähnhardt-Pfeiffer4, Siegfried Fürtauer5, Michelle Hesler1, Christoph Metzger3, Marielle Fink6, Dominik Selzer7, Thorsten Lehr7, Tobias Krebs6, Sven van Lengen8, Sylvia Wagner1, Hagen von Briesen1, Felix Grimm9, Petra Weißhaupt10, Heiko Briesen3, Florian Meier2


1Fraunhofer-Institut für Biomedizinische Technik IBMT, Sulzbach, Germany; 
2Postnova Analytics GmbH, Landsberg, Germany, 
3Technische Universität München, Lehrstuhl für Systemverfahrenstechnik, Freising, Germany 
4Microscopy Services Dähnhardt GmbH, Flintbek, Germany
5Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV, Freising, Germany
6VITROCELL Systems GmbH, Waldkirch, Germany
7Universität des Saarlands, Klinische Pharmazie, Saarbrücken, Germany 
8GRÜNPERGA Papier GmbH, Grünhainichen, Germany 
9INFIANA Germany GmbH & Co. KG, Forchheim, Germany
10Umweltbundesamt, Dessau-Roßlau, Germany

 

This poster shows the hazard studies on the effect of oral and pulmonary CNC uptake. Therefore a miniaturized cloud exposure system has been developed to create an in vitro model simulating the lung and the GI tract.

 

Motivation
Renewable raw materials are increasingly demanded for sustainable packaging solutions, but due to often inadequate material properties, such as low barrier effect and processability, they usually cannot be used directly. With its excellent barrier properties against oxygen and mineral oil, cellulose nanocrystals (CNC) offer a promising alternative to fossil raw materials. However, before CNC can be used in new, environmentally friendly packaging materials, their human safety needs to be assessed first. The project NanoCELL deals with improved strategies for extracting and processing CNC from regenerative raw materials for later use in environmentally friendly packaging materials. NanoCELL thereby tackles the entire CNC life cycle from its production from cellulose-containing raw materials to targeted modifications to its eventual use as coating material.

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