Advanced in vitro exposure systems.

A setup to test toxicity of alcohol inhalation from consumer products

11. Mar. 2018

User Group Meeting 2018

Dr. Monique Manche1, Dr. Fabrice Nesslany2, Tobias Krebs3
1Laboratoires Anios, 59260 Lille-Hellemmes, France
2Laboratoire de toxicologie génétique, Institut Pasteur de Lille, 59000 Lille, France
3VITROCELL Systems GmbH, 79183 Waldkirch, Germany

 

Genotoxicity tests (in vitro micronucleus test and comet assay) have been conducted on p53 competent pulmonary cells, with alcohol administration as vapours to obtain data under conditions more representative of actual exposure conditions via the pulmonary route.

 

Background
Alcohol-based hand rubs (AbHR) contribute significantly to the prevention of nosocomial infections. The alcohol content in these products is high so as to provide rapid antimicrobial efficacy, with amounts that can exceed 80 % w/w. Mostly used alcohols are ethanol, propan-2-ol and propan-1-ol. The objective of the research was to perform a comparative evaluation of these 3 alcohols in terms of respiratory toxicity, highlighting, where appropriate, the impact of increasing concentrations. 


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