Advanced in vitro exposure systems.

Exposure of human lung cells to inhalable substances

30. Mar. 2003

Taylor & Francis

Inhalation Toxicology, 15:67-84, 2003

Authors
Detlef Ritter, Jan W. Knebel, Michaela Aufderheide

 

The experimental setup included online monitoring of the gas phase and particulate phase. A cell exposure of different smoke and synthetic air periods was sufficient to cause different effects as measured by intracellular glutathione content. The fact that the system could differentiate between different types of cigarette smoke demonstrated its high sensitivity and specificity. 

A novel test strategy involving celan air exposure periods using whole dilution cigarette mainstream smoke.

 

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