7 doses @ 6 replicates 1 control @ 6 replicates Higher Throughput VITROCELL® 6/48 Climatic Chamber Exposure Module For 48 cell culture inserts (6-well size) The VITROCELL® 6/48 module system has been specifically designed and engineered to facilitate the research of mammalian cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure. Only one system is required: 7 dilutions with 6 inserts are used for exposure to the substances and 6 inserts in the same system for clean air control. The cells are exposed at the air/ liquid interface on 48 cell culture inserts using low flow rates of the aerosol. A complete dose / response profile can be obtained in one experiment . After exposure, the cells are further processed to measure a wide range of endpoints, e. g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation (see also VITROCELL® assay guide). Easy access to all components Heating Systems for base module and climatic chamber to avoid effects of aerosol condensation. 22
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