VITROCELL Systems

Base module Cell culture insert (6-well size) Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top. The aerosol inlet-stream flows through specifically shaped inlets. They are available in stainless steel or stainless steel with unique VITROGLIDE surface Aerosol exposure top treatment for lowest adhesion results. The stainless steel / VITROGLIDE inlets are specifically designed for aerosols containing nanoparticles. The aerosol inlets are connected to the distribution or dilution systems. Extraction from the module takes place via small holes using a controlled vacuum flow. VITROCELL® calibration valves, which are connected to a vacuum pump, control flow rates effectively. The aerosol exposure top features an in/outlet for heating the water circuit , ensuring corresponding temperatures with the base module. It is made of high-quality anodized aluminum. Optional media volume reduction units (3 ml) (static supply only) Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems Optional microbalance sensor for dose monitoring The base module has been designed for 6 cell culture inserts. The media are supplied individually to each well compartment . Optionally, media exchange can be carried out on a continuous Available adaptor set for: ○ 12-well sized inserts ○ Snapwell® inserts ○ 24-well sized inserts basis using a precision media pump. Temperature is electronically controlled at 37° C (99° F) by means of a heated base plate. Therefore, an additional incubator is not required while using this module. The base module is made of electropolished stainless steel. It is autoclavable at 121° C (250° F) for 20 min. This module is renowned in scientific circles for its reliability and durability. Features ○ Suitable for COSTAR®, FALCON® and ThinCert® 6-well sized cell culture inserts ○ Individual media inlets for each row of 3 insert compartments ○ Base module made of stainless steel for maximum durability ○ Control window for monitoring culture media levels ○ Hyperboloid geometry of inlets for optimized particle deposition and distribution ○ Available inlet materials: Stainless steel, stainless steel with unique VITROGLIDE surface treatment ○ Heating base plate with electronic control ○ An additional incubator is not required while using this module ○ Autoclavable at 121° C (250° F) 21

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