VITROCELL Systems

Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems ○ Easy handling ○ Only small quantities of powder needed (5–100 mg) ○ No external airflow required ○ Exposure time < 30 minutes ○ Optional continuous media supply or media sampling ○ Optional magnetic stirring for media compartment ○ Intuitive user experience with touchscreen operation Features Small powder samples of 5–100 mg are positioned in the quick-lock loading system. Subsequent aerosolisation of the powder takes place under high pressure by a unique jet system. The resulting shear forces facilitate deagglomeration for homogeneous dispersion into the expansion chamber. Final deposition takes place via gravimetric settling. The height of the expansion chamber can be varied in three different steps according to the behaviour and properties of the powder sample. For handling of the inserts the expansion chamber can be seperated effort-free from the exposure module. Quick-lock loading system open (left) and closed (right). Medium size expansion chamber – standby (left) and sealed (right). 1. P owder sample is placed in quick-lock loading system. 2. E xpansion chamber and base module are tightly sealed by touchscreen operation. 3. P owder sample is aerosolized under high ­ pressure to break up agglomerates for homo- geneous dispersion in the expansion chamber. 4. Powder sample settles on cell cultures. Working Principle The base module is prepared for continuous or timebased sampling from the media compartment . 77

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