VITROCELL Systems

○ Suitable for COSTAR®, FALCON® and ThinCert® 12-well sized cell culture inserts ○ Autoclavability of all components ○ Base module made of electropolished stainless steel for extreme durability ○ Electronic heating system ○ Base module and aerosol exposure top with integrated heating circuit ○ Hyperboloid geometry of inlets for optimized particle deposition and distribution ○ Control window for monitoring culture media levels Features Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems Aerosol exposure top Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top. The aerosol inlet-stream flows through specifically shaped inlets. They are available in stainless steel or stainless steel with unique VITROGLIDE surface treatment for lowest adhesion results. The stainless steel / VITROGLIDE inlets are specifically designed for aerosols containing nanoparticles. The aerosol inlets are connected to the distribution or dilution systems. Extraction from the module takes place via small holes using a controlled vacuum flow. VITROCELL® calibration valves, which are connected to a vacuum pump, control flow rates effectively. The aerosol exposure top features an in/outlet for heating the water circuit , ensuring corresponding temperatures with the base module. It is made of high-quality anodized aluminum. Base module The VITROCELL® 12/12 modules’ casing is made of electropolished stainless steel. It is designed with 12 (4x3) compartments for 12-well cell culture inserts and is fully autoclavable at 121° C (250° F) for 20 min. The capability to expose with up to 4 dilutions or 3 dilutions plus 1 clean-air control in a compact module is its’ outstanding feature. A transparent control window facilitates the external monitoring of media levels. Through the employment of a special adapter set , this module can also be flexibly combined for use with 24-well cell culture inserts. A constant unit temperature is guaranteed using an electronic temperature control. The media can be supplied individually for each row of 3 compartments. This module is renowned in scientific circles for its reliability and durability. Cell culture insert (12-well size) Available adaptor set for: ○ 24-well sized inserts Optional microbalance sensor for dose monitoring 39

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