VITROCELL Systems

VITROCELL® 12/12 Exposure Module For 12 cell culture inserts (12-well size) The VITROCELL® 12/12 module system has been specifically designed and engineered to facilitate the research of human cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure. Normally only one system is required: 3 dilutions with 3 inserts each are used for for exposure to the substances and 3 inserts in the same system for clean air control. Each dilution represents a different dose concentration, so that a complete dose/ response profile can be obtained in one experiment . The cells are exposed at the air / liquid interface on 12 cell culture inserts using low flow rates of the aerosol. After exposure, the cells are further processed to measure a wide range of endpoints, e. g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation (see also VITROCELL® assay guide). Culture media supply The media is supplied to the module by gravimetric method or syringe. 3 doses @ 3 replicates 1 control @ 3 replicates Compact Design 38

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