Culture media supply The media is supplied to the module by gravimetric method, syringe or using a media pump for intermittent /continuous media exchange. VITROCELL® 12/6 CF Stainless Steel Exposure Module For 6 cell culture inserts (12-well size) The VITROCELL® 12/6 CF module system has been specifically designed and engineered to facilitate the research of human cell cultures in direct exposure to airborne substan- ces such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure. Normally 3 compartments are used for exposure to the substances and 3 compartments for clean air control. The capacity can be easily increased by adding more modules. Each module can receive a different dose concentration, so that a complete dose/ response profile is obtained in one experiment . The cells are exposed at the air/liquid interface on 6 cell culture inserts using low flow rates of the aerosol. After expo- sure, the cells are further processed to measure a wide range of endpoints, e. g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation (see also VITROCELL® assay guide). VITROCELL® 12/6 CF Dynamic Dilution System and rack 34
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