VITROCELL Systems

○ Suitable for COSTAR®, FALCON® and ThinCert® 12-well sized cell culture inserts ○ For higher troughput ○ Autoclavability of all components ○ Base modules’ casing made of electropolished stainless steel for extreme durability ○ Base module with water heated base plate ○ Integration of the hyperboloid geometry of inlets into the aerosol exposure top ○ Dynamic dilution system part of delivery ○ Option: Control window for monitoring culture media levels Features The VITROCELL® 12/6 modules are made of electropolished stainless steel. They are designed with six compartments for 12-well cell culture inserts and are fully autoclavable at 121° C (250° F) for 20 min. A transparent control window facilitates the external monitoring of media levels. Through the employment of a special adapter set , this module can also be flexibly Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top. The aerosol inlet-stream flows through specifically shaped inlets. They are available in stainless steel or stainless steel with unique VITROGLIDE surface treatment for lowest adhesion results. The stainless steel / VITROGLIDE inlets are specifically designed for aerosols containing nanoparticles. The aerosol inlets are connected to the distribution or dilution systems. Extraction from the module takes place via small holes using a controlled vacuum flow. VITROCELL® calibration valves, which are connected to a vacuum pump, control flow rates effectively. The aerosol exposure top features an in/outlet for heating the water circuit , ensuring corresponding temperatures with the base module. It is made of high-quality anodized aluminum. combined for use with 24-well cell culture inserts. A constant unit temperature is guaranteed using a regulated flow of temperature-­ controlled water through the module. The media can be supplied gravimetrically using a bottle or syringe. This module is renowned in scientific circles for its reliability and durability. Base module Aerosol exposure top with central aerosol supply Available adaptor set for: ○ 24-well sized inserts Cell culture insert (12-well size) Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems 33

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