VITROCELL® 12/3 and 12/4 CF Stainless Steel Exposure Module For 3 or 4 cell culture inserts (12-well size) Normally two modules are required: one module for exposure to the substances and a second module for clean air control. The capacity can be easily increased by adding more modules. Each module can receive a different dose concentration, so that a The VITROCELL® 12 CF module system has been specifically designed and engineered to facilitate the research of human cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure. complete dose/ response profile is obtained in one experiment . The cells are exposed at the air / liquid interface on 3 cell culture inserts using low flow rates of the aerosol. After exposure, the cells are further processed to Culture media supply The media is supplied to the module by gravimetric method, syringe or using a media pump for intermittent /continuous media exchange. measure a wide range of endpoints, e. g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation (see also VITROCELL® assay guide). 28
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