Advanced in vitro exposure systems.

3. Apr. 2015

New VITROCELL® Cloud ALI (Air-Liquid Interface) Starter Kit

SOT and ToxExpo 2015. San Diego, USA.

Ready-to-use and economical solution for users starting to expose cell cultures at the air-liquid interface.

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20. Feb. 2015

Repeated exposure to carbon nanotube-based aerosols does not affect the functional properties of a 3D human epithelial airway model

Nanotoxicology, Early Online: 1–11 (doi: 10.3109/17435390.2014.993344)

Authors
Savvina Chortarea1, Martin J. D. Clift1, Dimitri Vanhecke1, Carola Endes1, Peter Wick2, Alke Petri-Fink1, and Barbara Rothen-Rutishauser1
1Department of BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Marly, Switzerland and
2Laboratory for Materials-Biology Interactions, EMPA, Swiss Federal Laboratories for Materials, Science and Technology, St. Gallen, Switzerland

Exposition of Carbone Nanotubes on 3D lung models in the air-liquid interface exposure system to measure oxydative stress and inflammatory response.

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23. Sep. 2014

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

High aspect ratio nanoparticles (HARN) were analyzed at the air/liquid interface using VITROCELL Cloud technology.

Particle and Fibre Toxicology 2014, 11:40 (doi:10.1186/s12989-014-0040-x)

Authors
Carola Endes1, Otmar Schmid2, Calum Kinnear1, Silvana Mueller3, Sandra Camarero-Espinosa3, Dimitri Vanhecke1, E. Johan Foster3, Alke Petri-Fink1,4, Barbara Rothen-Rutishauser1, Christoph Weder3 and Martin J.D. Clift.

1 BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
2 Comprehensive Pneumology Centre, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
3 Polymer Chemistry and Materials, Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
4 Department of Chemistry, University of Fribourg, Fribourg, Switzerland

 

High aspect ratio nanoparticles (HARN) were analyzed at the air-liquid interface using the VITROCELL® Cloud technology. The successful approach towards investigation of the hazard of HARN aerosols in vitro are demonstrated by measured cytotoxicity, oxidative stress and inflammatory responses. 

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20. May. 2014

VITROCELL User Group Meeting

Meeting featuring the new VITROCELL® Automated Exposure Station

International scientists from Europe, Japan, Korea and USA followed the invitation of VITROCELL® Systems to the 2014 User Group Meeting in the Europa-Park Rust, Germany.

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28. Apr. 2014

Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured at air-liquid interface conditions

Am J Respir Cell Mol Biol

First published online 28 Apr 2014 (doi: 10.1165/rcmb.2013-0479OC)

Authors
Anke-Gabriele Lenz1, Tobias Stoeger1, Daniele Cei2, Martina Schmidmeir1, Nora Pfister1, Gerald Burgstaller1, Bernd Lentner1, Oliver Eickelberg3, Silke Meiners1 and Otmar Schmid1

1 Helmholtz Zentrum München, Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Neuherberg/Munich, Germany
2 University of Pisa, Interdepartmental Research Center E.Piaggio”, Faculty of Engineering, Pisa, Italy
3,1 Ludwig-Maximilians-University, University Hospital, Munich, Germany

Introduction of the VITROCELL®-CLOUD (air-liquid interface cell exposure system-cloud) technology, which utilizes principles of cloud motion for fast and quantitative delivery of aerosolized liquid drugs to pulmonary cells cultured under realistic air-liquid interface conditions. These data indicate that the VITROCELL®-CLOUD is a reliable tool for aerosolized drug screening on cells.

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30. Jul. 2013

New on ICT Seoul

VITROCELL® Cloud

Exposure System for Liquid Aerosols with Cloud Dynamics.

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