Advanced in vitro exposure systems.

25. Jan. 2013

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers

American Journal of Physiology Lung Cellular and Molecular Physiology

2013 Apr 1;304(7):L489-503. doi: 10.1152/ajplung.00181.2012. [Epub ahead of print]

Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch M.

Philip Morris International, Neuchatel, Switzerland


The exposition of cigarette smoke on Human AIR-100 tissues shows equivalent results in MMP-1 release, gene expression and microRNA profiles to in vivo smokers' tissue.

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10. Mar. 2011

In vitro exposure of organotypical 3D epithelial tissues to cigarette smoke as a potential alternative to rodent inhalation studies

SOT Washington DC, USA

March 06-10, 2011

Weisensee, D., Kurkowsky, B., Hebestreit, M., Wagner, S. and Schueller J. 

Philip Morris Research Laboratories GmbH, Cologne, Germany, Abstract #998


Here we describe an in vitro test system that examines the toxicological effects of single or repeated cigarette smoke exposure on human organo- typically reconstituted 3D epithelial tissues. These tissues were exposed at the air liquid interface to either fresh air or to mainstream smoke from the Reference Cigarette 3R4F in the VITROCELL® system. 

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20. Mar. 2007

News Release

VITROCELL® 24 System for 24-well sized inserts

The new exposure system is a benchmark for in vitro research with higher throughput. It offers up to 6 doses @ 4 replicates in the 24-well size.

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