https://doi.org/10.3390/pharmaceutics10020056 

Julia Metz ^1,2, Katharina Knoth ¹, Henrik Groß ¹, Claus-Michael Lehr ^1,2,3, Carolin Stäbler ⁴, Udo Bock ⁵, and Marius Hittinger ^1
1Department of Drug Delivery, PharmBioTec GmbH, 66123 Saarbrücken, Germany
²Department of Biopharmaceutics and Pharmaceutical Technology, Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany
³Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123 Saarbrücken, Germany
⁴Department of Scientific Affairs Consumer Health, Bayer Vital GmbH, 51368 Leverkusen, Germany
⁵Bock Project Management, 54456 Tawern, Germany

In this study two innovative in vitro techniques were combined: The Vitrocell® Powder Chamber and the human cell based MucilAir™ system. Their combined use allows the investigation of the effect of aerosolized pollen and appropriate drugs on a human mucosal tissue, a similar scenario finding in humans. The release of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) was quantified as an initial cellular response to pollen contact and to confirm the protective effect of drugs.

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Following the VITROCELL® User Group Meeting 2017 in Baltimore, international scientists from Canada, Europe, Japan and USA reconvened in March 2018.

The informal event organized into short presentations and posters was followed by open discussions. It was an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange your experience in working with the equipment and to meet other fellow researchers. The meeting took place prior to the international Society of Toxicology 57th Annual Meeting and ToxExpo, March 11 – 15, 2018, in San Antonio, USA - one of the largest international conferences related to toxicology.

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Following the VITROCELL® User Group Meeting 2016 in New Orleans, international scientists from Canada, Europe, Japan, Korea and USA reconvened in March 2017.

The meeting offered an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange experiences in working with VITROCELL® devices and to meet fellow researchers. It was held prior to the International Society of Toxicology 56th Annual Meeting and ToxExpo – one of the largest international conferences related to toxicology.

Focus of the event was to exchange latest research results, to give an update on VITROCELL’s participation in major European and German research programs as well as the presentation of new products for 2017.

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