https://doi.org/10.1016/j.envres.2020.110350

Emeline Seurat ^a, Anthony Verdin ^b, Fabrice Cazier ^c, Dominique Courcot ^b, Richard Fitoussi ^d, Katell Vi´e ^d, Val´erie Desauziers ^e, Isabelle Momas ^a, Nathalie Seta ^a, Sophie Achard ^a
a Laboratoire de Sant´e Publique et Environnement, Hera “Health Environmental Risk Assessment”, Inserm UMR1153-CRESS (Centre de Recherche en Epid´emiologie et StatistiqueS), Universit´e de Paris, Facult´e de Pharmacie de Paris, 4, Avenue de L’Observatoire, 75006, Paris, France
^b Unit´e de Chimie Environnementale et Interactions sur le Vivant UR4492, SFR Condorcet FR CNRS 3417, Maison de La Recherche en Environnement Industriel 2, Universit´e Du Littoral Cˆote D’Opale, 189A Avenue Maurice Schumann, 59140, Dunkerque, France
^c Centre Commun de Mesures (CCM), Universit´e Du Littoral-Cˆote D’Opale, 145 Avenue Maurice Schumann, 5914, Dunkerque, France
^d Laboratoires Clarins, 5 Rue Amp`ere, 95300, Pontoise, France
^e IPREM, IMT Mines Ales, Universit´e de Pau et des Pays de L’Adour, E2S UPPA, CNRS, Pau, France

In the course of this study, they tested various pollutants with different chemical compositions, applying them to the apical side of Reconstructed Human Epidermis and being particularly interested in the effect relative humidity has on the reaction to pollutants. Investigating several cytokines and chemokines, they showed that IL-1α, IL-6, IL-8, and RANTES are the cytokines/chemokines almost systematically induced by most pollutants.

Read more

Yvonne Kohl¹, Roland Drexel², Christine Herrmann³, Stephan Dähnhardt-Pfeiffer⁴, Siegfried Fürtauer⁵, Michelle Hesler¹, Christoph Metzger³, Marielle Fink⁶, Dominik Selzer⁷, Thorsten Lehr⁷, Tobias Krebs⁶, Sven van Lengen⁸, Sylvia Wagner¹, Hagen von Briesen¹, Felix Grimm⁹, Petra Weißhaupt¹⁰, Heiko Briesen³, Florian Meier²

¹Fraunhofer-Institut für Biomedizinische Technik IBMT, Sulzbach, Germany; 
²Postnova Analytics GmbH, Landsberg, Germany, 
³Technische Universität München, Lehrstuhl für Systemverfahrenstechnik, Freising, Germany 
⁴Microscopy Services Dähnhardt GmbH, Flintbek, Germany
⁵Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV, Freising, Germany
⁶VITROCELL Systems GmbH, Waldkirch, Germany
⁷Universität des Saarlands, Klinische Pharmazie, Saarbrücken, Germany 
⁸GRÜNPERGA Papier GmbH, Grünhainichen, Germany 
⁹INFIANA Germany GmbH & Co. KG, Forchheim, Germany
¹⁰Umweltbundesamt, Dessau-Roßlau, Germany

This poster shows the hazard studies on the effect of oral and pulmonary CNC uptake. Therefore a miniaturized cloud exposure system has been developed to create an in vitro model simulating the lung and the GI tract.

Read more

https://doi.org/10.1186/s12989-020-00376-w

Yaobo Ding^1,2 , Patrick Weindl1,2,3, Anke-Gabriele Lenz^1,2, Paula Mayer^1,2, Tobias Krebs³ and Otmar Schmid^1,2
1Institute of Lung Biology and Disease, Helmholtz Zentrum München, 85764 Neuherberg, Germany
²Comprehensive Pneumology Center, Munich (CPC-M) - Member of the German Center for Lung Research (DZL), 81377 Munich, Germany
³VITROCELL Systems GmbH, 79183 Waldkirch, Germany.

This study provides evidence that QCMs are suitable for real-time dosimetry in particle toxicology studies with cell cultures under air-liquid interface conditions. An experimental method for determination of LoD (lower limit of detection), accuracy and precision of QCMs using a fluorescent tracer (fluorescein salt) was presented and applied to the QCMs integrated in the VITROCELL® Cloud 6 and Cloud 12 aerosol-cell exposure systems.

Read more

New designs of electronic cigarettes such as ENDS (Electronic Nicotine Delivery Systems) products or HTP (Heated Tobacco Products) lead to a large variety of different shapes which make the insertion into conventional holders with labyrinth seals impossible. VITROCELL® has developed a new holder system which is flexible to adjust to different shapes.

VITROCELL Application Note

Read more

https://doi.org/10.1016/j.tiv.2020.104950

Authors

Rui-WenHe^ab, Miriam E.Gerlofs-Nijland^a, JohnBoere^a, PaulFokkens^a, DaanLeseman^a, Nicole A.H.Janssen^a, Flemming R.Cassee^ab
a National Institute for Public Health and the Environment (RIVM), P.O. Box, 3720, BA, Bilthoven, the Netherlands
^b Institute for Risk Assessment Sciences, Utrecht University, P.O. Box 80178, 3508, TD, Utrecht, the Netherland

Highlights

• Airport and road traffic UFPs can activate inflammation in Calu-3 cells.
• Airport UFPs exert similar toxicity compared to UFPs from road traffic emission.
• ALI condition promotes cellular responses to particles at low exposed dose.

Read more