Advanced in vitro exposure systems.

31. Aug. 2009

SOT Meeting Baltimore

SOT Conference from March 15-19, 2009 in Baltimore/USA

VITROCELL® presented turnkey in vitro test systems for nano particles, gases and complex mixtures at the 2009 SOT Annual Meeting in Baltimore.

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23. Mar. 2009

Lung toxicity determination by in vitro exposure at the air-liquid interface with an integrated online dose measurement

Nanosafe 2008: International Conference on Safe production and use of nanomaterials

Journal of Physics: Conference Series 170 (2009) 012008 (doi:10.1088/1742-6596/170/1/012008)

Authors
Sonja Mülhopt, S. Diabaté, T. Krebs, C. Weiss and H.-R. Paur

Institute for Technical Chemistry, Thermal Waste Treatment Division, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
VITROCELL Systems GmbH, 79183, Waldkirch, Germany

 

Human lung cell cultures are exposed to airborne nanoparticles in VITROCELL®system modules. After exposure the cells are analyzed to measure the biological responses of the viability (LDH, AlamarBlue) as well as the release of IL-8. Using fluorescein sodium particles shows a very good correlation between the sensor signal of the quartz crystal microbalance and the deposited mass on the membranes shown by spectroscopy. This system for the first time provides an online dose measurement for in vitro experiments with nanoparticles. 

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31. Oct. 2008

EUROTOX

45th Congress of the European Societies of Toxicology in Rhodes, Greece from October 5-8, 2008

The VITROCELL® in vitro test systems for the analysis of the effects of nanoparticles and airborne pollutants found strong interest during EUROTOX 2008. Now online dose determination is possible via an integrated Quartz Crystal Microbalance (QCM).

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8. Oct. 2008

Online dose determination for in vitro experiments with nano particles in the Karlsruhe Exposure System

EUROTOX. Rhodes, Greece.

October 5-8, 2008

Authors
S. Mülhopt, H.-R. Paur, T. Krebs

Forschungszentrum Karlsruhe, Eggenstein – Leopoldshafen, Germany
VITROCELL Systems GmbH, Waldkirch, Germany

 

Poster about the exposition of airborne nanoparticles to human lung cell cultures in VITROCELL®system modules. After exposure the cells are analyzed to measure the biological responses of the viability (LDH, AlamarBlue) as well as the release of IL-8. Using fluorescein sodium particles shows a very good correlation between the sensor signal of the quartz crystal microbalance and the deposited mass on the membranes shown by spectroscopy. This system for the first time provides an online dose measurement for in vitro experiments with nanoparticles. 

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