Advanced in vitro exposure systems.

3. Oct. 2013

A modified Ames methodology for the assessment of mainstream cigarette smoke genotoxicity using an aerosol-based exposure system

Poster CORESTA SSPT Meeting. Seville, Spain.

29 September - 3 October 2013

Authors
David Thorne1, Joanne Kilford2, Rebecca Payne2, Annette Dalrymple1, Julie Clements2, Clive Meredith1, Debbie Dillon1

1 British American Tobacco, Group R&D, Southampton, United Kingdom
2 Covance Laboratories Ltd, Harrogate, North Yorkshire, United Kingdom

 

The successfull exposure of whole smoke on a modified AMES assay using the the air-liquid interface exposure system. 

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3. Sep. 2013

Characterisation of a Vitrocell® VC 10 in vitro smoke exposure system using dose tools and biological analysis

Chemistry Central Journal 2013, 7:146

doi:10.1186/1752-153X-7-146

Authors
David Thorne1, Joanne Kilford2, Rebecca Payne2, Jason Adamson1, Ken Scott1, Annette Dalrymple1, Clive Meredith1 and Deborah Dillon1

1 British American Tobacco, Group R&D, Southampton, United Kingdom
2 Covance Laboratories Ltd, Harrogate, North Yorkshire, United Kingdom

 

The study demonstrated that the VC 10® can produce stable tobacco smoke dilutions by particulate deposition, measured vapour phase, smoke marker delivery and biological responses from two independent in vitro test systems. 

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15. Apr. 2013

VITROCELL User Group Meeting

Ascot, United Kingdom

A total of 29 scientists from China, Europe, India, Japan and USA followed the invitation of VITROCELL® Systems to the 2013 User Group Meeting.

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31. Mar. 2013

New on SOT San Antonio

New Dosimetry Software

The new upgrade is the perfect tool for online dose monitoring using VITROCELL photometers and/or crystal quartz microbalances.

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Categories: Product News

Tags: microbalance, photometer

31. Mar. 2013

New on SOT San Antonio

VITROCELL® 12/4 Module

The new exposure module for inserts in the 12-well and 24-well size offers space to integrate a quartz crystal microbalance.

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12. Mar. 2013

Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

Chemistry Central Journal 2013, 7:50

doi:10.1186/1752-153X-7-50

Authors
Jason Adamson, David Thorne, Annette Dalrymple, Debbie Dillon, Clive Meredith

British American Tobacco, Group R&D, Southampton SO15 8TL, UK

 

A successfull technology to quantify the whole smoke particle deposition in vitro, in real-time, is given by the installation of Quartz crystal microbalances in a Vitrocell® Module.

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19. Apr. 2012

Dose Determination of Airborne Particles for In Vitro Exposure at the Air / Liquid Interface

Safety assessment of nanomaterials: current status and challenges ahead

IVTIP Spring Meeting 2012. April 19, 2012, Bilbao, Spain.

Authors
Marco Hebestreit and Tobias Krebs

Vitrocell Systems GmbH, Waldkirch, Germany

 

Demonstration of the the usability and reliability of the Crystal Quartz Microbalance. Using tobacco smoke and salt solution shows the potential of the system for dose determination and online monitoring.

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30. Jul. 2010

New on IUTOX

VITROCELL® Microbalance

The ideal tool for monitoring of partcle deposition in the exposure module.

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31. Mar. 2010

SOT Meeting Salt Lake City, USA

VITROCELL® Quartz Crystal Microbalance System for nano particle dose measurement in turnkey in vitro exposure systems.

VITROCELL® presented advanced solutions for the exposure of cells to airborne nano particles, gases and complex mixtures at the 2010 SOT Annual Meeting in Salt Lake City / USA.

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11. Sep. 2009

The QCM - Online Dose Measurement with high relative Humidity

European Aerosol Conference. Karlsruhe, Germany.

September 06-11, 2009

Authors
S. Mülhopt, A. Comouth, A. Grotz, T. Krebs, H.-R. Paur

Institute for Technical Chemistry, Thermal Waste Treatment Division, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
Institute for Meteorology and Climate Research, Atmospheric Aerosol Research Department, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
VITROCELL Systems GmbH, Waldkirch, Germany

 

The shown method first time provides an online dose measurement for in vitro exposure experiments at the air-liquid interface also under high humidity conditions.  Human lung cell cultures were tested for different biological responses like the viability (LDH, AlamarBlue) as well as the release of IL-8.

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