DOI: 10.1089/aivt.2017.0042

David Thorne, Emma Bishop, Linsey Haswell, and Marianna Gaca
British American Tobacco Group R&D, Southampton, United Kingdom

This case study has demonstrated that dosimetry techniques using particulate markers can allow in vitro biological data generated on five independent aerosol exposure system studies, under contrasting experimental designs and with different cell types, to be directly compared.

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Following the VITROCELL® User Group Meeting 2017 in Baltimore, international scientists from Canada, Europe, Japan and USA reconvened in March 2018.

The informal event organized into short presentations and posters was followed by open discussions. It was an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange your experience in working with the equipment and to meet other fellow researchers. The meeting took place prior to the international Society of Toxicology 57th Annual Meeting and ToxExpo, March 11 – 15, 2018, in San Antonio, USA - one of the largest international conferences related to toxicology.

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Marius Hittinger,¹ Sarah Barthold,² Lorenz Siebenbürger,¹ Kilian Zäh,³ Alexander Gress,¹ Sabrina Guenther,¹ Birgit Wiegand,¹ Carsten Boerger,¹ Markus Berger,⁴ Tobias Krebs,⁴ Henrik Groß,¹ and Claus-Michael Lehr¹,<sup>5

1</sup>PharmBioTec GmbH, Saarbrücken, Germany
²Saarland University, Department of Pharmacy, Saarbrücken, Germany
³Scienceneering UG, Blieskastel, Germany
⁴Vitrocell Systems GmbH, Waldkirch, Germany
⁵Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), HZI, Saarbrücken, Germany

The VITROCELL® Dry Powder Chamber is designed for aerosol deposition of different sized particles separated by their time of flight. For the development of this new instrument salbutamol sulphate was successfully exposed to human pulmonary epithelial cell culture by sedimentation and diffusion in vitro.

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Nala Rogers for 'Inside Science'

A report about artificial lung reveals surprising dangers from pellet burners and diesel-fueled ships at the University of Rostock and Helmholtz Zentrum München in Germany.

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DOI 10.1186/s12989-016-0171-3

Thomas Loret^1,2, Emmanuel Peyret¹, Marielle Dubreuil¹, Olivier Aguerre-Chariol³, Christophe Bressot³, Olivier le Bihan³, Tanguy Amodeo³, Bénédicte Trouiller¹, Anne Braun¹, Christophe Egles^2,4 and Ghislaine Lacroix¹

¹Institut National de l’Environnement Industriel et des Risques (INERIS), (DRC/VIVA/TOXI), Parc Technologique ALATA—BP 2, Verneuil-en-Halatte F-60550, France.
²Laboratoire BioMécanique et BioIngénierie (BMBI), Université de Technologie de Compiègne (UTC), UMR CNRS 7338, Compiègne 60205, France.
³Institut National de l’Environnement Industriel et des Risques (INERIS), (DRC/CARA/NOVA), Parc Technologique ALATA—BP 2, Verneuil-en-Halatte F-60550, France.
⁴Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
 

A549 alveolar cells in monocultures and in co-cultures with THP-1 macrophages were exposed to aerosols of inhalable and poorly soluble nanomaterials. The results are evaluated by using the Alamar blue®, LDH, Dichlorofluorescein (DCF) and ELISA Assay and shows that the air-liquid interface represents a valid and sensitive method to assess the toxicity of several poorly soluble nanomaterials.

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