Sivakumar Murugadoss 1, Sonja Mülhopt 2, Silvia Diabaté 3, Manosij Ghosh 1, Hanns-Rudolf Paur 2,
Dieter Stapf 2, Carsten Weiss 3, and Peter H. Hoet 1,
1 Laboratory of Toxicology, Unit of Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium
2 Institute for Technical Chemistry, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany
3 Institute of Biological and Chemical Systems—Biological Information Processing, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany
In this study, they investigated the influence of agglomeration on the deposition and cytotoxic potency of TiO2 NMs at the ALI. Our results indicate that dose deposition and the cytotoxic potential are influenced by agglomeration, particularly for nano-sized TiO2 particles.