Advanced in vitro exposure systems.

30. Nov. 2020

Product News 12/2020

VITROCELL® 12/12 now available with Climatic Chamber

For reliable aerosol exposure of cell cultures using 12- or 24-well sized inserts

The VITROCELL® 12/12 module system has been designed to facilitate the exposure of mammalian cell cultures to airborne substances such as gases, complex mixtures, nanoparticles and fibers. It features a throughput of 3 dilution steps @ 3 replicates and 1 clean air control at 3 replicates. In order to optimize the exposure for liquid aerosols and to maximize the performance of humidified air supply it is now also available in a user-friendly climatic chamber.

VITROCELL® 12/12 now available with Climatic Chamber

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28. Nov. 2020

Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles

doi:10.3390/nano10122369

Lars B. Leibrock 1, Harald Jungnickel 1, Jutta Tentschert 1, Aaron Katz 1, Blaza Toman 2 , Elijah J. Petersen 3 , Frank S. Bierkandt 1, Ajay Vikram Singh 1 , Peter Laux 1 and Andreas Luch 1
1 German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany; 
2 Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaitherburg, MD 20899-8311, USA; 
3 Materials Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaitherburg, MD 20899-8311, USA; 

 

ALI systems are considered to be a promising exposure system to study toxicological e ects of airborne nanomaterials instead of in vivo inhalation studies and have been widely used to assess the toxicology of nanomaterials in recent years. However, the robustness of these methods is not yet wellunderstood. Here we reported a C&E analysis of a commonly used flow through ALI exposure system.

 

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22. May. 2017

Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures

DOI: 10.1039/c7tx00109f
Jose Zavala,a Rebecca Greenan,b Q. Todd Krantz,a David M. DeMarini,a Mark Higuchi,a M. Ian Gilmour a and Paul A. Whiteb

aNHEERL, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
bMechanistic Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada.


The aim of this study was to test whether temperature and relative humidity has an influence on the cytotoxicity to BEAS-2B cells on a VITROCELL® 6 air-liquid interface system by measuring the viability (WST-1 cell proliferation assay) and lactate dehydrogenase (LDH) release.
Note from VITROCELL: We inform our customers about the possible need for humidification during installation and training. Among the need for humidification, possible other reasons for low clean air viability are clean air quality and cell handling procedures. Please see our website chapter on humidification for further information http://www.vitrocell.com/inhalation-toxicology/humidification

 

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31. Mar. 2012

New on SOT San Francisco

VITROCELL® Humidification Station

The new reliable tool for humidification of dilution air.

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Categories: Product News

Tags: humidification

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