Advanced in vitro exposure systems.

21. Mar. 2015

Automatisiertes Expositionssystem für Zellkulturen an der Gas-Flüssigkeits-Grenzschicht

Feinstaub in der Lunge

(Automated exposure system for cell cultures at the air/liquid interface / article in German)

Sonja Mülhopt, Tobias Krebs, Dr. Silvia Diabaté, Christoph Schlager, Dr. Hanns-Rudolf Paur


Zur Analyse von gasgetragenen Nano- und Feinstpartikel werden Bioassays mit menschlichen Lungenzellkulturen durchgeführt. Mit dem automatisierten Vitrocell-Expositionssystem können Aerosole reproduzierbar auf die Zellen aufgebracht werden.

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20. May. 2014

VITROCELL User Group Meeting

Meeting featuring the new VITROCELL® Automated Exposure Station

International scientists from Europe, Japan, Korea and USA followed the invitation of VITROCELL® Systems to the 2014 User Group Meeting in the Europa-Park Rust, Germany.

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30. Nov. 2012

Unique Experiment in Rostock

Scientists are investigating the fine dust from marine diesel using new VITROCELL® 6/6

How does the exhaust from marine diesel engines act on human health? This has been investigated by devoted scientists from eight research institutions in Europe at the University of Rostock.

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11. Sep. 2009

Biological effects in human lung cells exposed to platinum nanoparticle aerosol

European Aerosol Conference. Karlsruhe, Germany.

September 06-11, 2009

S. Diabaté, C. Weiss, S. Mülhopt, H.-R. Paur, V. Niedetzky, M. Seipenbusch

Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, 76021, Karlsruhe, Germany
Institute for Technical Chemistry, Forschungszentrum Karlsruhe, 76021, Karlsruhe, Germany
Institute for Mechanical Process Engineering and Mechanics, University Karlsruhe, 76131, Karlsruhe, Germany


For the bioassay they exposed platinum nanoparticles to BEAS-2B and A549 cells, both co-cultured with differentiated THP-1 macrophages, growing on Transwell inserts. The responses of the cells were analyzed by measuring the viability, LDH and IL-8. 

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