Advanced in vitro exposure systems.

15. Mar. 2012

Utilization of a whole smoke exposure system for the comparison of mainstream cigarette smoke, gas vapor phase and tar mutagenicity

SOT San Francisco, USA

March 11-15, 2012; Poster #1843

Authors
Robert D. Leverette

Life Sciences, A.W. Spears Research Center, Lorillard Tobacco Company, Greensboro, NC 27405, USA

 

This study was conducted to optimize smoke exposure procedures, measure the mutagenicity of mainstream cigarette whole smoke, the gas vapor phase and wet total particulate matter (WTPM) as determined by the Ames Assay.

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10. Mar. 2011

Comparison of the bacterial mutagenicity of mainstream whole smoke from cigarettes with different levels of menthol

SOT Washington DC, USA

March 06-10, 2011

Authors
Robert D. Leverette

Life Sciences, A. W. Spears Research Center, Lorillard Tobacco Company, Greensboro, NC 27405, USA

 

This study was conducted to compare the mutagenicity of mainstream whole-smoke and wet total particulate matter from two sets of experimental cigarettes to determine if menthol has an effect on this endpoint. All cigarettes were smoked under ISO on a VITROCELL® VC10 smoking robot. TA98 and TA100 were exposed in the VITROCELL® Ames exposure modules.

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23. Jul. 2007

A modified Ames assay reveals the mutagenicity of native cigarette mainstream smoke and its gas vapour phase

ELSEVIER

Experimental and Toxicologic Pathology 58 (2007) 383-392

Authors
Michaela Aufderheide, Helga Gressmann

Department of In-Vitro Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany

 

Establishment of a new experimental approach for direct exposure of bacteria with actual generated smoke aerosol. This allowed us to investigate the mutagenic activity of native mainstream smoke on Salmonella Typhimurium strains. The new procedure of exposing bacteria directly to gases and complex mixtures offers new possibilities in the field of inhalation genotoxicology for the evaluation of genotoxicity in the Ames assay.

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31. Dec. 2004

A modified CULTEX® system for the direct exposure of bacteria to inhalable substances

URBAN & FISCHER

Exp Toxic Pathol 2004; 55: 451-454

Authors
Michaela Aufderheide and Ulrich Mohr

 

Establishment of a novel experimental approach using an exposure device based on the cell exposure system CULTEX. This allows to investigate chemically and physically unchanged atmospheres like mainstream cigarette smoke by exposing bacteria of Salmonella typhimurium strains directly on the surface of culture media.

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Comments (0) Number of views (1964)
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